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Shuangge Jiecheng Pill: Protective Effects and Applications
Protective Effects on Alcoholic Fatty Liver
Alcoholic Fatty Liver Disease (AFLD) Treatment
Shuangge Jiecheng Pill (SG) has demonstrated significant protective effects against alcoholic fatty liver disease (AFLD) in rat models. Studies have shown that SG can reduce the activity of liver enzymes such as γ-glutamyltransferase (GGT), alanine aminotransferase (ALT), and aspartate aminotransferase (AST), which are typically elevated in AFLD . Additionally, SG treatment has been associated with a decrease in liver indexes and an increase in body weight, indicating an overall improvement in liver health and function.
Mechanisms of Action
The hepatoprotective effects of SG are attributed to its ability to promote alcohol metabolism, reduce fat accumulation in the liver, and alleviate hepatocellular damage. SG has been shown to enhance the activity of alcohol dehydrogenase (ADH) and hepatic tissue protein (HTP), while reducing levels of uric acid (UA) and alkaline phosphatase (AKP). These biochemical changes contribute to the mitigation of fatty degeneration and inflammation in the liver, highlighting SG's potential as an effective treatment for AFLD.
Antidepressant Effects and Gut Microbiota Modulation
Depression Treatment
Shugan Jieyu Capsule (SG), another formulation containing Hypericum perforatum L. (St John’s Wort), has been widely used in China to treat mild to moderate depression. Research indicates that SG can reverse depression-like behaviors in rats subjected to chronic unpredictable mild stress (CUMS) by modulating the gut microbiota. This modulation includes increasing the richness and uniformity of gut flora and altering the relative abundance of specific bacterial families and genera, such as Lactobacillaceae and Bifidobacterium.
Mechanisms of Antidepressant Action
SG's antidepressant effects are linked to its ability to regulate the hypothalamic-pituitary-adrenal (HPA) axis, as evidenced by decreased corticosterone levels and increased serotonin levels in treated rats. The changes in gut microbiota are also associated with improved metabolic pathways, including carbohydrate and amino acid metabolism, which may contribute to the overall antidepressant effects of SG.
Cytotoxicity and Safety Profile
Cytotoxicity Evaluation
Swasanandam Gutika (SG), a traditional rasa formulation, has been evaluated for its cytotoxicity using the MTT assay in mouse fibroblast cells. The results indicate that SG is safe and non-cytotoxic at concentrations below 125 μg/ml, making it a viable option for treating respiratory illnesses in children. This safety profile is crucial given the presence of potentially toxic ingredients like Hingula and Vatsanabha in the formulation.
Cardioprotective Effects in Myocardial Infarction
Myocardial Infarction (MI) Treatment
ShenZhuGuanXin granules (SG) have shown promise in mitigating cardiac dysfunction and promoting myocardium angiogenesis in rat models of myocardial infarction. SG treatment improves cardiac hemodynamic function, reduces infarct size, and increases microvessel density by upregulating the expression of PECAM-1/CD31 and VEGF. These findings suggest that SG could be a valuable therapeutic option for patients with coronary heart disease (CHD).
Conclusion
Shuangge Jiecheng Pill and its related formulations exhibit a wide range of therapeutic effects, from protecting against alcoholic fatty liver disease to treating depression and myocardial infarction. The hepatoprotective, antidepressant, and cardioprotective properties of these formulations are supported by robust biochemical and physiological evidence, making them promising candidates for further clinical research and application.
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