Side effects of b12 shots

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Side Effects of B12 Shots

Allergic Reactions to Cyanocobalamin Injections

One of the notable side effects of B12 shots, specifically cyanocobalamin injections, is the potential for allergic reactions. A documented case involved a 63-year-old woman who experienced redness, tenderness, and itching at the injection site following each administration of cyanocobalamin. Additionally, oral ingestion of cyanocobalamin triggered similar reactions at previous injection sites. This patient also had positive patch test reactions to cobalt chloride and cyanocobalamin solutions, indicating a hypersensitivity to these substances .

Side Effects from Proprietary Vitamin B12 Preparations

In a study involving a large number of intramuscular injections of a proprietary vitamin B12 preparation derived from Streptomyces griseus fermentation liquors, several side effects were observed. This preparation, used for treating pernicious anemia, raised concerns about whether the side effects were due to the vitamin B12 itself or contaminants within the preparation. The study aimed to identify the factors that might predispose individuals to these adverse effects .

Conclusion

While B12 shots are essential for individuals with certain deficiencies, they can cause side effects, including allergic reactions and other adverse effects potentially linked to contaminants in the preparation. It is crucial for healthcare providers to monitor patients for these reactions and consider alternative forms of administration if necessary.

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Most relevant research papers on this topic

B12 Shots—Still Another Side of the Coin

Cyanocobalamin injections may cause allergic reactions, even when they are therapeutically needed, and their use should be based on a patient's specific needs and tolerance levels.

Case Report

1975·

0citations

·A. Fisher

JAMA·

DOI

Side-effects of a Preparation of Vitamin B12

Vitamin B12 injections from Streptomyces griseus fermentation liquors may cause side-effects, and factors like age and gender may predispose to their occurrence.

1952·

18citations

·P. Bedford

British Medical Journal·

DOI

Type 1 hypersensitivity from vitamin B12 injection: a case report

Intramuscular cyanocobalamin injections for vitamin B12 deficiency can cause rare, life-threatening anaphylactic reactions, highlighting the need for vigilant healthcare providers.

Case Report

2022·

0citations

·E. M. Khatrawi et al.

International Journal of Research in Medical Sciences·

DOI

Vitamin B12 supplementation during pregnancy and postpartum improves B12 status of both mothers and infants but vaccine response in mothers only: a randomized clinical trial in Bangladesh

Vitamin B12 supplementation during pregnancy and lactation improves maternal, infant, and breast milk B12 status, but only improves H1N1 vaccine-specific responses in mothers.

RCTRigorous JournalHighly Cited

2016·

96citations

·T. Siddiqua et al.

European Journal of Nutrition·

DOI

The vitamin B12 absorption test, CobaSorb, identifies patients not requiring vitamin B12 injection therapy

The CobaSorb vitamin B12 absorption test can identify patients not requiring injection therapy, potentially reducing costs and inconvenience for patients.

Observational Study

2011·

22citations

·A. Hvas et al.

Scandinavian Journal of Clinical and Laboratory Investigation·

DOI

Anaphylactic reaction after intramuscular injection of cyanocobalamin (vitamin B12): a case report.

Anaphylactic reaction to vitamin B12 is a rare but serious side effect, especially when administered via the parenteral route.

Case Report

2005·

18citations

·F. Bilwani et al.

JPMA. The Journal of the Pakistan Medical Association

Anaphylactic Reaction to Cyanocobalamin: A Case Report

Anaphylactic reaction is a rare but potentially life-threatening side effect of intramuscular cyanocobalamin, highlighting the need for vigilant healthcare providers when administering this treatment to vitamin B12 deficient patients.

Case Report

2018·

8citations

·Muhammad Wajih Ullah et al.

Cureus·

DOI

Cyanocobalamin-induced anaphylactic reaction

Anaphylactic reactions to Vitamin B12 are a rare but serious side effect, and should be closely monitored during patient administration, especially when using the parenteral route.

Case Report

2023·

0citations

·Cyril Sajan et al.

Journal of the Scientific Society·

DOI

Effect of physiological doses of oral vitamin B12 on plasma homocysteine – A randomized, placebo-controlled, double-blind trial in India

Daily oral supplementation with physiological doses of vitamin B12 effectively reduces plasma total homocysteine levels, without additional benefits or adverse effects.

RCTLarge Human Trial

2010·

53citations

·Urmila S. Deshmukh et al.

European journal of clinical nutrition·

DOI

Intranasal treatment of vitamin B12 deficiency in children

Intranasal application of vitamin B12 is a safe and effective alternative to intramuscular injections in children with vitamin B12 deficiency, leading to higher compliance and less burden for patients.

Case ReportVery Rigorous Journal

2019·

22citations

·G. F. Estourgie-van Burk et al.

European Journal of Pediatrics·

DOI

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