Side effects of norvasc

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Side Effects of Norvasc (Amlodipine)

Introduction to Norvasc (Amlodipine)

Norvasc, also known by its generic name amlodipine, is a calcium channel blocker commonly prescribed to treat high blood pressure and angina. While it is effective in managing these conditions, it is important to be aware of its potential side effects.

Common Side Effects of Norvasc

Edema and Swelling

One of the most frequently reported side effects of Norvasc is edema, particularly in the legs. In a study involving 152 patients, leg edema was observed in 10.5% of the participants . Another case report highlighted bipedal pitting edema as a side effect, which resolved after discontinuation of the drug .

Headaches and Dizziness

Headaches and dizziness are also common side effects. In the same study of 152 patients, headaches were reported by 2% of the participants, and dizziness was noted in a few cases . These symptoms are generally mild and transient.

Less Common but Notable Side Effects

Gingival Hyperplasia and Telangiectasia

A rare combination of gingival hyperplasia (overgrowth of gum tissue) and telangiectasia (small dilated blood vessels) was reported in a 3-year-old patient. This unusual side effect was directly linked to the use of amlodipine .

Conjunctival Chemosis

Conjunctival chemosis, a condition characterized by swelling of the conjunctiva, was reported in a 69-year-old man. This side effect, along with bipedal edema, appeared three months after starting Norvasc and resolved six months after stopping the medication .

Conclusion

While Norvasc (amlodipine) is an effective medication for managing hypertension and angina, it is associated with several side effects. Common issues include leg edema, headaches, and dizziness, while less common but notable side effects include gingival hyperplasia, telangiectasia, and conjunctival chemosis. Patients should be aware of these potential side effects and consult their healthcare provider if they experience any unusual symptoms.

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Most relevant research papers on this topic

Telangiectasia and gingival hyperplasia as side-effects of amlodipine (Norvasc) in a 3-year-old girl.

Amlodipine (Norvasc) is a potential cause of telangiectasia and gingival hyperplasia in children, but the specific combination of these side-effects was not previously described.

Case Report

1999·

51citations

·C. Vleuten et al.

Acta dermato-venereologica·

DOI

-Efficacy and safety of using amlodipine in treatment of mild and moderate essential hypertension-.

Amlodipine is an efficient and well-tolerated antihypertensive drug for patients with mild and moderate essential hypertension, with mild and transient side effects.

Non-RCT

1995·

0citations

·F. Kokot et al.

Polskie Archiwum Medycyny Wewnetrznej

Comparative study of Yashida and Norvasc in chronic renal insufficiency with hypertension

Yashida 5mg or 10mg daily is as effective and safe as Novasc in treating hypertension in chronic renal insufficiency patients.

RCT

2012·

0citations

·Wang Cai-xia

Strait Pharmaceutical Journal

Chronic Conjunctival Chemosis From Amlodipine Besylate (Norvasc)

Amlodipine besylate (Norvasc) may cause conjunctival chemosis and bipedal edema in the eye, with resolution 6 months after discontinuing the medication.

Case Report

2011·

5citations

·E. Say et al.

Cornea·

DOI

Overview of the prospective randomized evaluation of the vascular effects of Norvasc (amlodipine) trial: PREVENT.

Amlodipine reduces carotid intima-media thickness progression and significantly reduces unstable angina hospital admissions, but does not affect minor coronary lesions.

2000·

4citations

·G. Mancini

The Canadian journal of cardiology

Does amlodipine increase cancer incidence?

Amlodipine does not increase cancer risk or progression of coronary atherosclerosis in this 36-month randomized trial.

RCT

2001·

7citations

·M. Goldstein

Circulation·

DOI

Effect of Domestic Amlodipine Besylate Tablets on Hypertension

Domestic amlodipine besylate tablets effectively and safely treat hypertension as Norvasc, with little adverse reactions.

RCT

2008·

0citations

·Hu Chun-li

Chinese Journal of General Practice

Rationale, design, and baseline characteristics of the Prospective Randomized Evaluation of the Vascular Effects of Norvasc Trial (PREVENT).

The PREVENT trial aims to determine if Norvasc can slow or reverse early coronary atherosclerosis progression in patients with documented disease.

1997·

67citations

·R. Byington et al.

The American journal of cardiology·

DOI

Confusing Press Releases and the PREVENT Study.

The PREVENT study showed no significant reduction in cardiovascular morbidity and mortality events compared to placebo, but the study's results were influenced by the press releases.

2001·

1citation

·F. Messerli

Circulation·

DOI

[Comparative anti-hypertensive effectiveness and tolerance of drugs in patients with mild and moderate arterial hypertension].

Dilren (300 mg/day), norvask (5-10 mg/day) and invoril (10-20 mg/day) are effective and safe in treating mild and moderate arterial hypertension, while caposide (1 tablet a day) fails to provide adequate blood pressure reduction throughout 24 hours.

Non-RCT

1999·

0citations

·Nesterov IuI et al.

Klinicheskaia meditsina

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