Skin collagen before and after hair
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Impact of Collagen on Skin and Hair Health
Fish-Derived Collagen Hydrolysate and Hair Growth
Fish-derived collagen hydrolysate (CH) has shown significant promise in enhancing hair and skin health. Studies have demonstrated that CH extracted from Mozambique tilapia scales can mitigate oxidative stress and inflammation, which are critical factors in hair and skin health. In vitro studies using human dermal papilla cells (hDPCs) revealed that CH increases levels of growth factors such as IGF-1 and VEGF while reducing inflammatory markers like TGF-β1, TNF-α, and IL-1β. In vivo experiments on C57BL/6 mice showed that CH treatment improved various hair growth parameters, including hair length, diameter, weight, and density, and also enhanced skin health by promoting extracellular matrix factors.
Collagen VI and Wound-Induced Hair Growth
Collagen VI, an extracellular matrix molecule, plays a complex role in hair follicle growth. Research indicates that collagen VI is highly expressed in hair follicles and upregulated by skin wounding. Interestingly, the absence of collagen VI in Col6a1(-/-) mice delays normal hair cycling but promotes wound-induced hair regrowth. This effect is mediated through the activation of the Wnt/β-catenin signaling pathway, suggesting that collagen VI could be a potential therapeutic target for hair loss and other skin-related conditions.
Fish Collagen Peptides and Hair Regrowth
Fish collagen peptides (CPs) from Mozambique tilapia scales have been found to promote hair regrowth and enhance skin health. In vitro studies showed that CPs significantly increased the proliferation of hDPCs. In vivo studies on C57BL/6 mice confirmed these findings, showing that CP treatment significantly enhanced hair regrowth and upregulated hair growth factors such as IGF-1, VEGF, and Ki67, while downregulating inhibitory factors like TGF-β1. These effects were mediated through the modulation of the Wnt/β-catenin and BMP signaling pathways, indicating that CPs could be effective as nutraceuticals for hair loss prevention and treatment.
Oral Supplements Containing Hydrolyzed Collagen
Oral supplements containing hydrolyzed collagen, along with amino acids like methionine, taurine, and cysteine, have shown potential benefits for individuals with hair loss conditions such as androgenetic alopecia (AGA) or telogen effluvium (TE). These supplements have demonstrated beneficial effects on nail and skin health and could improve hair growth, although controlled clinical data are still needed to confirm their efficacy.
Collagen Remodeling During Hair Cycle Stages
The remodeling of type I collagen in the dermis varies significantly between different stages of the hair cycle. Research on C3H mice has shown that the amount of newly synthesized collagen is higher during the anagen (growth) phase compared to the telogen (resting) phase. Additionally, post-translational modifications of collagen, such as lysine and proline hydroxylation, are more pronounced during the anagen phase, facilitating an environment conducive to hair follicle migration and growth.
Conclusion
Collagen, particularly fish-derived collagen hydrolysate and peptides, plays a crucial role in enhancing hair and skin health by mitigating oxidative stress, reducing inflammation, and promoting hair growth. The remodeling of collagen during different hair cycle stages further underscores its importance in hair follicle health. These findings suggest that collagen-based treatments and supplements could be effective strategies for improving hair and skin health.
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