Sodium bicarbonate with omeprazole
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Sodium Bicarbonate with Omeprazole: Efficacy and Stability
Introduction to Omeprazole and Sodium Bicarbonate Combination
The combination of omeprazole, a proton pump inhibitor (PPI), and sodium bicarbonate, an antacid, has been developed to enhance the treatment of acid-related disorders. This combination aims to provide rapid and sustained acid suppression, which is beneficial for conditions such as gastroesophageal reflux disease (GERD) and peptic ulcers.
Acid Inhibitory Effects
Studies have shown that the combination of immediate-release omeprazole and sodium bicarbonate (CDFR0209) is as effective as delayed-release omeprazole in reducing gastric acidity. In a crossover study involving healthy adult males, both formulations significantly decreased integrated gastric acidity at steady state, with no significant difference between them1. This suggests that the combination can provide effective acid suppression comparable to traditional delayed-release formulations.
Treatment of Helicobacter pylori Infection
When used in combination with antibiotics for the treatment of Helicobacter pylori infection, omeprazole and sodium bicarbonate have shown mixed results. A study comparing omeprazole-amoxicillin therapy with ranitidine-sodium bicarbonate-amoxicillin therapy found poor cure rates for both regimens, indicating that neither combination was particularly effective for H. pylori eradication2. This highlights the need for more effective treatment protocols for this infection.
Stability and Administration
The stability of omeprazole-sodium bicarbonate formulations is crucial for their effectiveness. Research indicates that omeprazole-sodium bicarbonate suspensions remain stable for up to 45 days when refrigerated, retaining at least 98% of their initial concentration4. Additionally, these suspensions can be easily administered through neonatal and pediatric feeding tubes, making them suitable for use in various patient populations4.
Efficacy in Gastroesophageal Reflux Disease (GERD)
Systematic reviews have assessed the efficacy of omeprazole-sodium bicarbonate in treating GERD. While the combination is not significantly more effective than omeprazole alone, it tends to provide a more sustained response and quicker relief of symptoms5 6. This can be particularly beneficial for patients requiring rapid symptom control.
Clinical Applications and Recommendations
The combination of omeprazole and sodium bicarbonate has also been explored for treating laryngopharyngeal reflux (LPR). Clinical studies have shown that this combination can significantly improve symptoms and reduce pathological signs of LPR, with an effective rate of 92% in treated patients7. This suggests that the combination can be a valuable option for managing LPR.
Conclusion
The combination of omeprazole and sodium bicarbonate offers a promising approach for managing acid-related disorders, providing rapid and sustained acid suppression. While it is effective for conditions like GERD and LPR, its efficacy in treating H. pylori infection remains limited. The stability and ease of administration of omeprazole-sodium bicarbonate formulations further enhance their clinical utility, making them a versatile option for various patient populations.
Sources and full results
Most relevant research papers on this topic
Acid Inhibitory Effect of a Combination of Omeprazole and Sodium Bicarbonate (CDFR0209) Compared With Delayed‐Release Omeprazole 40 mg Alone in Healthy Adult Male Subjects
CDFR0209 and delayed-release omeprazole 40 mg are equally effective in decreasing integrated gastric acidity in healthy adult male subjects.
RCT
Very Rigorous JournalTreatment of Helicobacter pylori infection with omeprazole-amoxicillin combination therapy versus ranitidine/sodium bicarbonate-amoxicillin.
Both omeprazole and high dose of ranitidine plus sodium bicarbonate plus amoxicillin therapies failed to effectively treat Helicobacter pylori infection.
RCTBioequivalence Study of Two Oral-Capsule Formulations of Omeprazole 20 mg in Combination with Sodium Bicarbonate in Healthy Mexican Adult Volunteers
The immediate-release formulation of omeprazole 20 mg in combination with sodium bicarbonate is bioequivalent to the delayed-release formulation in treating gastritis, reflux, heartburn, and emptiness caused by excessive acid production in healthy Mexican adult volunteers.
Non-RCTStability of Partial Doses of Omeprazole–Sodium Bicarbonate Oral Suspension
Omeprazole-sodium bicarbonate oral suspension is stable for 45 days, stable with partial doses, and easily administered through neonatal and pediatric feeding tubes, making it cost-effective compared to lansoprazole.
Efficacy of omeprazole/sodium bicarbonate treatment in gastroesophageal reflux disease: a systematic review.
Omeprazole/sodium bicarbonate therapy is not more effective than omeprazole in treating gastroesophageal reflux disease, but it may provide more sustained relief and relief by 30 minutes.
Systematic ReviewEfficacy of omeprazole/sodium bicarbonate treatment in gastroesophageal reflux disease: a systematic review.
Omeprazole/sodium bicarbonate therapy is not more effective than omeprazole in treating gastroesophageal reflux disease, but may provide more sustained relief and relief by 30 minutes.
Systematic ReviewClinical efficacy of omeprazole enteric-coated tablets plus sodium bicarbonate spray on the treatment of iaryngopharygeal reflux
Omeprazole enteric-coated tablets and sodium bicarbonate spray effectively relieve or improve symptoms and pathology of laryngopharygeal reflux in 92% of patients.
Non-RCT[Acid suppression capacity of omeprazole, sodium bicarbonate and alginic acid in an oral powder combination].
The oral powder combination of omeprazole, sodium bicarbonate, and alginic acid effectively suppresses gastric acid, providing faster but equally sustained control compared to delayed-release proton pump inhibitors.
Non-RCT