Combining multi-pinhole SPECT and micro-CT allows for in vivo evaluation of bone regeneration in implants, aiding in optimizing bone-inducing biomaterials.

Longitudinal in vivo evaluation of bone regeneration by combined measurement of multi-pinhole SPECT and micro-CT for tissue engineering

Nuclear imaging techniques, such as PET and SPECT, offer promising tools for implant research, providing specific, quantitative, and non-invasive feedback on biomaterials and transplanted cells.

Implant Imaging: Perspectives of Nuclear Imaging in Implant, Biomaterial, and Stem Cell Research

Non-invasive techniques, such as SPECT/CT and microCT, can effectively monitor growth factor retention and bone formation in drug delivery-based bone regeneration strategies.

Non-invasive monitoring of BMP-2 retention and bone formation in composites for bone tissue engineering using SPECT/CT and scintillation probes.

Metal artifacts in CT can significantly affect bone metabolism quantification, but optimizing protocols can minimize this effect.

Quantitative imaging of bone remodeling in patients with a unicompartmental joint unloading knee implant (ATLAS Knee System)—effect of metal artifacts on a SPECT-CT-based quantification

SPECT/CT performance in tracking transplanted cells is strongly influenced by biological variables, and considering these factors is crucial for planning experiments and developing SPECT/CT technology for cell tracking.

Sci‐Fri PM Imaging‐11: Evaluation of SPECT/CT for Regenerative Medicine Applications: Tracking Transplanted Cells in a Large Animal Model

Quantitative SPECT imaging has become viable with advances in multimodality -cameras and image reconstruction techniques, achieving accuracy within 10% of known radiotracer concentrations in vivo.

An Evidence-Based Review of Quantitative SPECT Imaging and Potential Clinical Applications

SPECT/CT has advanced Nuclear Medicine imaging, with new techniques and deep-learning approaches expected in the future.

Recent Developments in SPECT/CT.

SPECT/CT with (111)In-WBC and (99m)Tc-sulfur colloid is the best imaging technique for diagnosing bone and joint infections, while FDG-PET is useful for osteomyelitis diagnosis with improved spatial resolution.

PET and SPECT in osteomyelitis and prosthetic bone and joint infections: a systematic review.

This study developed a non-invasive imaging platform that combines SPECT, MRI, and CT/CT to follow bone metastasis growth and potentially detect treatment responses in small animal models.

Bone metastasis imaging with SPECT/CT/MRI: a preclinical toolbox for therapy studies.

This study developed and validated a technique for in vivo three-dimensional semiquantitative analysis of bone using CT and SPECT images, warranting further in vivo trials.

Spatial and temporal registration of CT and SPECT images: development and validation of a technique for in vivo three-dimensional semiquantitative analysis of bone.

The metal artifact reduction (MAR) method improves the quantitative accuracy of SPECT/CT imaging in patients with metal implants, regardless of the CT dose.

Metal artifact reduction for improving quantitative SPECT/CT imaging

SPECT/CT imaging improves sensitivity and specificity in diagnosing various oncological and non-oncological diseases, with potential applications in minimally invasive surgery and cardiovascular patients.

A review on the clinical uses of SPECT/CT

SPECT/CT imaging of the extremities is valuable for diagnosing abnormal bone turnover, providing anatomical correlation, and increasing confidence in diagnosis compared to conventional radiographs.

Clinical applications of SPECT/CT in imaging the extremities

Small-animal SPECT and SPECT/CT systems enable detailed molecular analysis, drug development, and therapeutic monitoring in small-animal models of disease.

Small-Animal SPECT and SPECT/CT: Important Tools for Preclinical Investigation*

Preclinical SPECT combined with CT or MRI is increasingly used in oncology and neuroscience research, offering potential for both neuroscience and oncological applications.

The role of preclinical SPECT in oncological and neurological research in combination with either CT or MRI

SPECT has poor sensitivity and specificity in diagnosing condylar hyperplasia, and 3D medical modeling shows potential for improving diagnosis accuracy.

Using 3D Medical Modeling to Evaluate the Accuracy of Single-Photon Emission Computed Tomography (SPECT) Bone Scintigraphy in Diagnosing Condylar Hyperplasia.

SPECT/CT is a routine imaging technique in most clinical fields, providing increased specificity and diagnostic confidence, but large-scale prospective studies are needed for neurology and lung disorders.

Two decades of SPECT/CT – the coming of age of a technology: An updated review of literature evidence

PET-CT has become the dominant molecular technique in oncology due to its superior resolution, speed, and quantitative capability, making it the preferred method for personalized cancer therapy.

Is there still a role for SPECT–CT in oncology in the PET–CT era?

MicroSPECT in small-animal models of cardiovascular disease allows for detailed exploration of heart function and pathology, aiding diagnostics, therapeutic interventions, and prognosis.

Small-animal SPECT and SPECT/CT: application in cardiovascular research

Fitting Gompertzian or logistic growth models to SPECT/CT imaging data effectively extracts useful biophysical parameters from breast tumors, improving treatment plans.

Experimental method and statistical analysis to fit tumor growth model using SPECT/CT imaging: a preclinical study.

spect-ct in research of implant in-growth

These studies suggest that SPECT/CT is a valuable tool for non-invasive, quantitative evaluation of bone regeneration and implant in-growth, though optimization is needed to address metal artifacts and biological variables.