How can I support my immune system during flu season?
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Supporting Your Immune System During Flu Season
Dietary Supplements for Immune Support
UP360 and UP446 Supplements
Research has shown that dietary supplements UP360 and UP446 can enhance immune function, particularly in response to influenza vaccination. These supplements have been found to activate the immune system, reduce inflammation, and protect against lung damage. In a clinical trial, participants who took UP360 or UP446 showed increased levels of TCRγδ+ cells and immunoglobulins IgA and IgG compared to a placebo group. Additionally, these supplements increased influenza B-specific IgG levels significantly post-vaccination, suggesting a robust humoral response.
Aged Garlic Extract (AGE)
Aged Garlic Extract (AGE) has also been studied for its immune-boosting properties. In a randomized, double-blind, placebo-controlled study, participants who consumed AGE showed better proliferation and activation of γδ-T and natural killer (NK) cells. Although the number of illnesses did not significantly differ between the AGE and placebo groups, the severity and duration of cold and flu symptoms were reduced in the AGE group. This suggests that AGE can enhance immune cell function and reduce the severity of respiratory infections.
Active Hexose Correlated Compound (AHCC)
AHCC, a natural mushroom extract, has been shown to increase NK cell activity and improve survival rates in young mice infected with influenza. Supplementation with AHCC led to increased NK activity in the lungs and spleen, reduced severity of infection, and faster recovery times. These findings indicate that AHCC can bolster innate immunity and improve the body's response to primary flu infections.
Probiotics and Fermented Foods
Yogurt with Lactobacillus delbrueckii ssp. bulgaricus
Consuming yogurt fermented with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 has been found to augment serum antibody titers against seasonal influenza vaccines. In clinical trials, participants who consumed this yogurt had higher serum antibody titers against influenza viruses and experienced fewer days of illness compared to those who took a placebo. This suggests that such yogurt can act as a mucosal adjuvant, enhancing acquired immune responses and reducing the duration of respiratory infection symptoms.
Vitamin D and Immune Function
Role of Vitamin D
Vitamin D plays a crucial role in modulating the immune system. It prevents excessive expression of inflammatory cytokines and enhances the antimicrobial activity of immune cells. Studies have shown that vitamin D deficiency is common in winter and is associated with an increased risk of respiratory infections. Supplementing with vitamin D can reduce the incidence of viral respiratory infections, making it a valuable nutrient for supporting immune health during flu season.
Vaccination and Immune Response
Importance of T-Cell Immunity
T-cell immunity is essential for protection against influenza. T cells targeting conserved internal influenza proteins can provide cross-protective immunity against different strains of the virus. Studies have shown that individuals with preexisting T-cell responses to influenza are less likely to develop symptomatic infections. This highlights the importance of vaccines that stimulate T-cell responses for broader and more effective protection against influenza .
Timing of Vaccination
Recent studies have raised concerns about waning immunity within a single influenza season, particularly with early vaccination. It is suggested that a more nuanced approach to vaccination timing could help maintain immunity during peak flu activity. This approach would consider both the duration of immunity and vaccination coverage to optimize protection throughout the flu season.
Conclusion
Supporting your immune system during flu season involves a combination of dietary supplements, probiotics, adequate vitamin D intake, and timely vaccination. Supplements like UP360, UP446, AGE, and AHCC can enhance immune function and reduce the severity of infections. Probiotics such as yogurt with Lactobacillus delbrueckii ssp. bulgaricus can boost antibody responses. Ensuring sufficient vitamin D levels and considering the timing of flu vaccinations can further strengthen your immune defenses. By integrating these strategies, you can better protect yourself against the flu and maintain overall health during the flu season.
Sources and full results
Most relevant research papers on this topic
A Randomized, Triple-Blind, Placebo-Controlled Clinical Trial Investigating Two Dietary Supplements on Supporting Immune Function in Healthy Adults in a Flu Vaccine Model
Aged Garlic Extract Modifies Human Immunity.
Systems Analysis of Immunity to Influenza Vaccination across Multiple Years and in Diverse Populations Reveals Shared Molecular Signatures.
Supplementation with active hexose correlated compound increases the innate immune response of young mice to primary influenza infection.
Consumption of yogurt fermented with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 augments serum antibody titers against seasonal influenza vaccine in healthy adults
Early Bird Gets the Flu: What Should Be Done About Waning Intraseasonal Immunity Against Seasonal Influenza?
Natural T Cell-mediated Protection against Seasonal and Pandemic Influenza. Results of the Flu Watch Cohort Study.
Epidemic influenza and vitamin D
Immune responses to influenza virus infection.
Indoor Staying During Winter Season Makes People More Susceptible to Flu.
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