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Some studies suggest that tamoxifen resistance in breast cancer can be influenced by various microRNAs, while other studies indicate that the Mirena IUD can alleviate tamoxifen-induced endometrial lesions but may have controversial effects on breast cancer recurrence.
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Tamoxifen is a widely used endocrine therapy for estrogen receptor-positive (ER+) breast cancer. However, its use is associated with resistance in many patients and potential adverse effects on the endometrium. The Mirena intrauterine device (IUD), which releases levonorgestrel, has been studied for its potential to mitigate these endometrial effects.
Tamoxifen Resistance and MicroRNAs:
Tamoxifen and Endometrial Effects:
Mechanisms of Tamoxifen Action:
Tamoxifen resistance in breast cancer is significantly influenced by various microRNAs, such as miR-519a, miR-320a, and miR-221/222, which regulate key genes and pathways. The Mirena IUD shows promise in mitigating tamoxifen-induced endometrial lesions, although its effects on breast cancer recurrence need further investigation. Understanding these mechanisms can help develop better therapeutic strategies to overcome resistance and manage side effects.
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