Thc in oil
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THC in Oil: Extraction, Concentration, and Therapeutic Applications
Extraction Methods for THC in Olive Oil
The extraction of THC from cannabis into olive oil has been a focus of recent research due to its therapeutic potential. A study developed and validated a new liquid chromatographic-tandem mass spectrometric (LC-MS/MS) method for identifying and quantifying THC and CBD in olive oil. The method involved diluting the olive oil with organic solvents and injecting the sample into the LC-MS/MS system. The results showed that the method was linear over a range of 0.1-10 ng/µL for both THC and CBD, with imprecision and accuracy within acceptable limits. The stability of THC in oil was confirmed for up to two months at room temperature when kept in the dark, while CBD showed a 30% degradation within ten weeks. The extraction efficiency was significantly influenced by the temperature, with a slight increase in temperature resulting in higher extraction percentages for both THC and CBD1.
THC Concentrations in Hempseed Oil
Hempseed oil, marketed for its nutritional benefits, also contains varying concentrations of cannabinoids, including THC. A study analyzed commercial hemp seeds and hempseed oil using gas chromatography-mass spectrometry (GC/MS). The THC concentrations in hempseed oil ranged from 0.3 to 19.73 µg/mL, while CBD concentrations ranged from 6.66 to 63.40 µg/mL. The study validated the GC/MS technique for its accuracy and precision in measuring these cannabinoids. The findings highlight the need for regulatory limits on THC in hempseed oil to ensure consumer safety2.
Therapeutic Use of THC-Rich Cannabis Oil
Fibromyalgia Treatment
A clinical trial investigated the effects of a THC-rich cannabis oil on fibromyalgia symptoms. The study involved 17 women and used a double-blind, placebo-controlled design over eight weeks. The cannabis oil contained 24.44 mg/mL of THC and 0.51 mg/mL of CBD. Results showed a significant decrease in the Fibromyalgia Impact Questionnaire (FIQ) scores for the cannabis group compared to the placebo group, indicating improved symptoms and quality of life. The study concluded that THC-rich cannabis oil could be a low-cost, well-tolerated therapy for fibromyalgia, although further research is needed to assess long-term benefits3.
Chemotherapy-Induced Nausea and Vomiting (CINV)
Another study evaluated the efficacy of a THC:CBD (1:1) oil in reducing chemotherapy-induced nausea and vomiting (CINV) in gynecologic cancer patients. The randomized, double-blind, placebo-controlled trial involved 54 participants. The results showed that the THC:CBD oil significantly reduced nausea scores compared to the placebo. However, side effects such as dizziness and sedation were common. The study concluded that THC:CBD oil is an effective adjuvant for reducing CINV, despite the side effects6.
Stability and Concentration of Cannabinoids in Cannabis Oil
A study assessed the concentration and stability of cannabinoids in cannabis oil using ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS). The extraction efficiency of oil was found to be higher than that of water, particularly for THC and CBD. The study also noted that pre-heating the cannabis material significantly increased the final concentrations of cannabinoids in the oil. The stability of cannabinoids in oil was higher than in tea, with up to 85% of the initial concentrations remaining after 14 days at ambient and refrigerated temperatures. This highlights the importance of standardized preparation protocols to ensure the therapeutic continuity of cannabis oil4.
Conclusion
The extraction and concentration of THC in oil, particularly olive and hempseed oil, have significant therapeutic implications. Validated methods for quantifying THC ensure the safety and efficacy of these preparations. Clinical trials have demonstrated the potential benefits of THC-rich cannabis oil in treating conditions like fibromyalgia and CINV, although side effects and long-term efficacy require further investigation. Standardized protocols for preparing cannabis oil are essential to maintain its therapeutic properties and ensure consistent patient outcomes.
Sources and full results
Most relevant research papers on this topic
Therapeutic Use of Δ9-THC and Cannabidiol: Evaluation of a New Extraction Procedure for the Preparation of Cannabis-based Olive Oil.
The developed method is simple, fast, and highly reproducible, making it suitable for routine extraction of THC and CBD from cannabis-based olive oil for therapeutic purposes.
Concentrations of THC, CBD, and CBN in commercial hemp seeds and hempseed oil sold in Korea.
The optimized methanol extraction-GC/MS technique effectively determines THC, CBD, and CBN concentrations in hemp seeds and hempseed oil, meeting regulatory limits for these cannabinoids.
Ingestion of a THC-Rich Cannabis Oil in People with Fibromyalgia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
THC-rich cannabis oil can be a low-cost, well-tolerated therapy that reduces symptoms and improves quality of life for fibromyalgia patients without intolerable adverse effects.
RCT
Rigorous JournalEvaluation of cannabinoids concentration and stability in standardized preparations of cannabis tea and cannabis oil by ultra-high performance liquid chromatography tandem mass spectrometry
Standardized preparation protocols for cannabis tea and oil are essential for ensuring therapeutic continuity and ensuring high cannabinoid concentrations.
Highly CitedA prospective open‐label trial of a CBD/THC cannabis oil in dravet syndrome
TIL-TC150, a CBD/THC cannabis oil, shows potential in reducing seizures and improving quality of life in children with Dravet syndrome.
RCTRigorous JournalHighly CitedOral Tetrahydrocannabinol (THC):Cannabinoid (CBD) Cannabis Extract Adjuvant for Reducing Chemotherapy-Induced Nausea and Vomiting (CINV): A Randomized, Double-Blinded, Placebo-Controlled, Crossover Trial
THC:CBD extract oil (1:1) effectively reduces chemotherapy-induced nausea and vomiting in gynecologic cancer patients, with dizziness and sedation being the major side effects.
RCTDetection of delta-9-tetrahydrocannabinol (THC) in oral fluid, blood and urine following oral consumption of low-content THC hemp oil.
Low-content THC hemp oil does not result in positive biological assessments, making it highly unlikely that ingestion of these products will negatively impact existing region-specific drug driving enforcement protocols.
Safety and Efficacy of Medical Cannabis Oil for Behavioral and Psychological Symptoms of Dementia: An-Open Label, Add-On, Pilot Study.
Adding medical cannabis oil containing THC to Alzheimer's disease patients' pharmacotherapy is a safe and promising treatment option for relieving behavioral and psychological symptoms.
Non-RCTRigorous JournalHighly CitedDetermination of cannabinoids in hemp oil based cosmetic products by LC-tandem MS
This study developed a reliable and efficient LC-MS/MS method for detecting THC, CBD, and CBN in hemp seed oil-based cosmetic products, providing valuable background information for administration purposes.
Disposition of cannabinoids and their metabolites in serum, oral fluid, sweat patch and urine from healthy individuals treated with pharmaceutical preparations of medical cannabis
Decoction of medical cannabis is generally better absorbed than oil, with higher THC and CBD absorption in oil and lower CBDA absorption in decoction.
Non-RCT