Searched over 200M research papers
10 papers analyzed
These studies suggest that non-TIA symptoms can still indicate a high risk of stroke, particularly in older adults and those with vascular disease, and that timely medical attention is crucial.
20 papers analyzed
Transient Ischemic Attacks (TIAs) are often referred to as "mini-strokes" due to their sudden onset and transient nature. However, not all sudden neurological symptoms are TIAs. This article explores the symptoms that mimic TIAs and the challenges in diagnosing these events.
Classic TIA symptoms include motor weakness, dysphasia, hemianopia, and monocular visual loss. These symptoms are typically focal, negative, and non-progressive, meaning they affect a specific part of the body, result in a loss of function, and do not worsen over time.
There are also non-consensus TIA symptoms such as isolated diplopia, dysarthria, vertigo, ataxia, sensory loss, and bilateral visual disturbance. These symptoms can be more challenging to diagnose and are often not immediately recognized as TIAs by patients or healthcare providers.
Patients with TIAs can sometimes present with nonfocal symptoms like unconsciousness, amnesia, and unsteadiness. These symptoms are more likely to be associated with acute ischemic lesions in the posterior circulation and arterial stenosis or occlusion in the posterior circulation. Despite these associations, the one-year risk of ischemic stroke does not significantly differ between patients with focal and nonfocal symptoms.
Nontraditional symptoms such as pain, mental status changes, lightheadedness, and headache are also reported. Women, in particular, are more likely to report nontraditional symptoms, especially altered mental status, compared to men. These symptoms can complicate the diagnosis and delay treatment.
Experts diagnose TIAs based on clinical features like negative symptoms or speech deficits. Positive symptoms, altered levels of consciousness, and non-focal symptoms like confusion or amnesia are more likely to be diagnosed as TIA mimics. The mode of onset, recurrence of attacks, and localizability of symptoms to a distinct vascular territory are crucial in the diagnostic process.
A significant challenge in TIA diagnosis is patient delay in seeking medical attention. More than a third of patients experiencing a TIA delay seeking medical help for more than a day, which critically extends the initiation of stroke preventive treatment. Factors associated with shorter delays include longer duration of symptoms, motor symptoms, higher ABCD2 scores, and correct patient recognition of the event as a possible ischemic cerebrovascular event.
Patients with non-consensus TIA symptoms have a similar 90-day stroke risk compared to those with classic TIA symptoms. However, they are less likely to seek medical attention on the day of the event and more likely to have recurrent strokes before seeking attention. The presence of motor impairments during a TIA significantly increases the risk of a subsequent stroke.
The long-term risk of stroke or myocardial infarction (MI) in patients with minor neurological symptoms not clinically diagnosed as TIA or minor stroke is also significant. Older patients and those with a history of vascular disease have a high risk of stroke or MI, regardless of the initial diagnosis.
Diagnosing TIAs can be complex due to the variety of symptoms that can mimic these events. Nonfocal and nontraditional symptoms add to the diagnostic challenge, often leading to delays in treatment. Understanding the full spectrum of TIA symptoms and their mimics is crucial for timely and accurate diagnosis, which is essential for effective stroke prevention.
Most relevant research papers on this topic