Top health supplement companies
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Top Health Supplement Companies
Ocular Nutritional Supplements: Leading Brands and Their Claims
Ingredients and Manufacturer Claims
The top-selling brands of ocular nutritional supplements in the United States have been scrutinized for their ingredient composition and the validity of their health claims. A study comparing these supplements with the Age-Related Eye Disease Study (AREDS) and AREDS2 formulae found that while all the supplements contained ingredients from these studies, only 36% had equivalent doses1. Furthermore, 55% of these products mentioned AREDS on their websites, but none provided evidence-based claims for primary prevention of eye disease1. This highlights the need for ophthalmologists to educate patients on the evidence-based role of these supplements in eye health management1.
Brain Health Supplements: Common Products and Ingredients
Online Promotion and Ingredient Analysis
Brain health supplements are widely promoted online, with products like Prevagen®, Procera®, and Neuro Health® being the most common2. These supplements often contain proprietary blends of ingredients such as Ginkgo biloba, vitamin B12, folic acid, huperzine-A, Bacopa monnieri, and phosphatidylserine2. Despite their popularity, there is minimal evidence supporting their efficacy in improving brain health or memory2. Health professionals need to be well-informed about these supplements to provide appropriate guidance to consumers2.
Dietary Supplements for Diabetes: Usage and Efficacy
Popular Ingredients and Clinical Evidence
The dietary supplement industry is a massive market, with estimated sales exceeding $30 billion in the US alone3. Many consumers believe that supplements are safer and more effective than drugs for managing diabetes. However, a comprehensive review of the literature revealed that only a few ingredients, such as fiber, selenium, and zinc, have substantial evidence supporting their benefits in diabetes management3. Other popular ingredients like phosphorus, calcium, and magnesium showed little to no clinical evidence of efficacy3. This underscores the importance of relying on scientifically validated supplements for diabetes control3.
Coenzyme Q10: Efficacy, Safety, and Formulation Challenges
Role in Noncommunicable Diseases
Coenzyme Q10 (CoQ10) is the third most consumed dietary supplement globally and is considered a potential treatment for various noncommunicable diseases, including cardiovascular and neurodegenerative diseases, cancer, and diabetes4. Research indicates that CoQ10 can play a significant role in reducing morbidity associated with these conditions4. However, there are challenges related to its formulation and ensuring its efficacy and safety4. As the demand for dietary supplements grows, it is crucial for dietitians, physicians, and policymakers to expand the scientific evidence base for these products4.
Conclusion
The health supplement industry is vast and varied, with numerous products claiming to offer significant health benefits. However, the evidence supporting these claims is often limited or non-existent. For ocular health, brain health, diabetes management, and noncommunicable diseases, it is essential to rely on supplements with proven efficacy and to remain cautious of unsubstantiated claims. Health professionals play a critical role in guiding consumers towards evidence-based supplement choices.
Sources and full results
Most relevant research papers on this topic
Ocular nutritional supplements: are their ingredients and manufacturers' claims evidence-based?
Most top-selling ocular nutritional supplements do not contain identical ingredient dosages as the AREDS or AREDS2 formula and have product descriptions with unsubstantiated claims, emphasizing the need for patient education on the evidence-based role of nutritional supplements in eye health management.
Observational StudyOnline Promotion of "Brain Health" Supplements.
Online promotion of "brain health" supplements is widespread, but their primary ingredients are similar and have insufficient evidence of efficacy and are expensive.
Observational StudyUse and abuse of dietary supplements in persons with diabetes
There is little clinical evidence for the use of dietary supplements to reduce or control diabetes, with fiber, selenium, and zinc showing the most studies associated with improvement.
Systematic Review
Very Rigorous JournalCoenzyme Q10 supplementation: Efficacy, safety, and formulation challenges.
Coenzyme Q10 supplementation shows potential in reducing morbidity and healthcare costs for various noncommunicable diseases, but more research is needed on its efficacy, safety, and formulation challenges.
Highly CitedTop-Funded Digital Health Companies And Their Impact On High-Burden, High-Cost Conditions.
Top-funded digital health companies have not yet demonstrated substantial impact on disease burden or cost in the US healthcare system.
Observational StudyChapter 8 – Health Supplements
Most scientific studies do not justify the use of health supplements, and it is better to consume natural food rather than rely on supplements.
Systematic ReviewA review of probiotic supplementation in healthy adults: helpful or hype?
Probiotic supplementation in healthy adults can improve immune system responses, gut microbiota concentration, and gastrointestinal health, but does not consistently cause persistent changes or improve blood lipid profile.
Systematic Review
Rigorous JournalHighly CitedAnalysis of Non-Hormonal Nutritional Supplements for Anabolic-Androgenic Steroids - Results of an International Study
94 (14.8%) non-hormonal nutritional supplements tested contained anabolic androgenic steroids not declared on the label, with most positive supplements purchased in the Netherlands, Austria, UK, and USA.
Observational StudyHighly CitedThe Enterprising Business of Nutritional Supplements: An Eye-Opener
Drafting nutritional supplement policies and legislation with education could protect consumers and safeguard manufacturers and distributors from adverse consequences.
Lifestyle and diet in people using dietary supplements
Dietary supplement use is highly prevalent and associated with healthier lifestyle and diet characteristics, but may also lead to lower meat, saturated fat, and n6/n3-fatty acid intake.
Observational StudyRigorous JournalHighly Cited