Vitamin b rash
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Vitamin B and Skin Reactions: A Comprehensive Overview
Vitamin B2 and Hand-Foot-and-Mouth Disease Rash
Therapeutic Effects of Vitamin B2
Vitamin B2, also known as riboflavin, has been studied for its potential benefits in treating hand-foot-and-mouth disease (HFMD). A study involving 90 children with HFMD investigated the effects of vitamin B2 as an adjuvant treatment alongside antiviral therapy. The results indicated that while vitamin B2 significantly shortened the time for active feeding and ulcer healing, it did not show a statistically significant difference in the time for defervescence and rash retrogression compared to the control group1. This suggests that while vitamin B2 may aid in some aspects of HFMD recovery, its impact on rash resolution is limited.
Vitamin B12 and Allergic Skin Reactions
Cobalt-Induced Urticaria from Vitamin B12 Injections
Vitamin B12, particularly in its injectable form, has been associated with various cutaneous reactions, including urticaria. A case study highlighted a woman who developed chronic urticarial plaques after starting intramuscular vitamin B12 injections. The reaction was suspected to be due to cobalt, a central metal ion in the vitamin B12 molecule. Prick and patch testing confirmed a cobalt allergy, and discontinuation of the vitamin B12 injections led to the resolution of the urticarial plaques2. This case underscores the importance of considering cobalt allergy in patients presenting with skin reactions following vitamin B12 supplementation.
Systemic Allergic Dermatitis to Cobalt in Vitamin B12
Another case involved a 69-year-old woman who developed a persistent erythematous-squamous rash after long-term oral vitamin B12 supplementation. Patch testing revealed a positive reaction to cobalt chloride, leading to a diagnosis of systemic allergic dermatitis (SDRIFE subtype). Discontinuation of the vitamin B12 supplements resulted in complete resolution of the dermatitis3. This further supports the link between cobalt in vitamin B12 and allergic skin reactions.
Topical Vitamin B12 for Eczema
Efficacy in Childhood Eczema
Topical vitamin B12 has been explored as a treatment for atopic dermatitis, commonly known as eczema. A double-blinded, randomized, placebo-controlled study evaluated its effectiveness in children aged 6 months to 18 years. The study found that skin treated with topical vitamin B12 showed significant improvement compared to placebo-treated skin at both 2 and 4 weeks4. This suggests that topical vitamin B12 could be a viable alternative treatment for eczema in children, potentially offering a safer option compared to topical steroids.
Conclusion
Vitamin B2 and B12 have distinct roles and effects on skin conditions. While vitamin B2 may aid in certain aspects of HFMD recovery, its impact on rash resolution is minimal. On the other hand, vitamin B12, particularly in its injectable form, can cause allergic skin reactions due to cobalt. However, topical vitamin B12 shows promise as an effective treatment for childhood eczema. Understanding these nuances is crucial for optimizing treatment strategies and managing potential adverse reactions.
Sources and full results
Most relevant research papers on this topic
Adjuvant effect of vitamin B_2 on hand-foot-and-mouth disease
Vitamin B2 shows a satisfactory adjuvant effect on hand-foot-and-mouth disease, reducing active feeding and ulcer healing times compared to jodine glycerin.
RCTCobalt-Induced Contact Urticaria Presenting as Chronic Urticaria Due to Intramuscular Vitamin B12 Injections.
Intramuscular vitamin B12 injections can cause chronic urticaria due to cobalt, and discontinuing the injections resolves the patient's symptoms.
Case ReportSystemic allergic dermatitis to cobalt present in cyanocobalamin supplementation
The patient's systemic allergic dermatitis resolved completely after discontinuing vitamin B12 supplementation due to cobalt exposure.
Case ReportEvaluation of topical vitamin B(12) for the treatment of childhood eczema.
Topical vitamin B(12) shows promise as an effective treatment option for children with eczema, improving skin quality significantly more than placebo.
RCTTopical vitamin K1 in the management of skin rash during anti-EGFR monoclonal antibody treatment in patients with metastatic cancer: Italian Observational Study.
Vitamin K1 cream shows a favorable impact in managing skin rash during anti-EGFR treatment in metastatic cancer patients.
Observational Study
Rigorous JournalVitamin D3 and deconvoluting a rash
High-dose systemic cholecalciferol may effectively treat severe reactions to topical chemotherapy, potentially reducing exaggerated immune responses.
RCTVitamin B12 Excretion in Patients with Various Skin Diseases
Vitamin B12 excretion may be reduced in patients with psoriasis, eczema, and other skin diseases, possibly due to malabsorption or increased tissue utilization.
Topical vitamin B12—a new therapeutic approach in atopic dermatitis—evaluation of efficacy and tolerability in a randomized placebo‐controlled multicentre clinical trial
Topical vitamin B12 may reduce pruritus and erythema in atopic dermatitis by scavenging nitric oxide, potentially improving patient comfort and quality of life.
RCTCombined zinc and vitamin B6 deficiency in a patient with diffuse red rash and angular cheilitis 6 years after Roux-en-Y gastric bypass
A combined zinc and vitamin B6 deficiency may cause a rash similar to acrodermatitis enteropathica in patients with prior Roux-en-Y gastric bypass surgery.
Case ReportPlural Nature of Vitamin B
Vitamin B carriers exposed to intense ultraviolet irradiation can cause severe dermatitis and death, while tikitiki, an alcoholic extract of rice polishings, can cause depletion, miserable appearance, and death.
Non-RCT
Animal Study