Vitamin b6 and nausea

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The Efficacy of Vitamin B6 in Treating Nausea

Vitamin B6 for Nausea and Vomiting in Pregnancy

Effectiveness in Severe Nausea

Vitamin B6, also known as pyridoxine, has been shown to significantly reduce the severity of nausea in pregnant women, particularly those experiencing severe symptoms. In a randomized, double-blind placebo-controlled study, women with severe nausea who received vitamin B6 reported a notable decrease in their nausea scores compared to those who received a placebo . This suggests that vitamin B6 can be an effective treatment for severe nausea during pregnancy.

Comparison with Other Treatments

Several studies have compared the effectiveness of vitamin B6 with other treatments for nausea and vomiting in pregnancy. For instance, a study comparing vitamin B6 and ginger found that while both treatments significantly reduced nausea and vomiting, ginger was slightly more effective in reducing the severity of nausea 269. Another study comparing vitamin B6 with dimenhydrinate, an antihistamine, concluded that both treatments were effective, but dimenhydrinate had a greater impact on reducing nausea and vomiting scores .

Combined Therapies

Research has also explored the combination of vitamin B6 with other treatments. For example, a study on the combination of doxylamine and vitamin B6 (Diclectin®) found that this combination was effective in reducing nausea and vomiting in pregnancy, with pyridoxal 5′ phosphate (PLP) being the active antiemetic form of vitamin B6 .

Vitamin B6 for Chemotherapy-Induced Nausea

Pediatric Cancer Patients

Vitamin B6 has also been studied for its effectiveness in reducing chemotherapy-induced nausea and vomiting (CINV) in pediatric cancer patients. A clinical trial demonstrated that vitamin B6 significantly reduced the severity of nausea and the frequency of vomiting episodes compared to a placebo, suggesting its potential as an adjunct treatment for CINV in children .

Conclusion

Vitamin B6 is a viable option for treating nausea and vomiting, particularly in pregnancy and chemotherapy-induced cases. It has been shown to be effective in reducing the severity of symptoms, especially in severe cases of nausea during pregnancy. While other treatments like ginger and dimenhydrinate may offer slightly better results in some cases, vitamin B6 remains a valuable and effective treatment option.

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Most relevant research papers on this topic

Vitamin B6 is effective therapy for nausea and vomiting of pregnancy: A randomized, double‐blind placebo‐controlled study

Vitamin B6 therapy significantly reduced the severity of nausea and the number of patients with vomiting in pregnant women with severe nausea compared to placebo.

RCTHighly Cited

1991·

189citations

·V. Sahakian et al.

Comparing ginger and vitamin B6 for the treatment of nausea and vomiting in pregnancy: a randomised controlled trial.

Ginger is more effective than vitamin B6 for relieving nausea severity and is equally effective for decreasing the number of vomiting episodes in early pregnancy.

RCTHighly Cited

2009·

150citations

·Jenabi Ensiyeh et al.

Effect of vitamin B6 on the side effects of a low-dose combined oral contraceptive.

Vitamin B6 may reduce the severity of oral contraceptive side effects, but its effectiveness is more likely due to a placebo effect than a marginal pharmacological effect.

RCT

1997·

23citations

·E. Villegas-Salas et al.

A randomized comparison of vitamin B6 and dimenhydrinate in the treatment of nausea and vomiting in early pregnancy

Dimenhydrinate is more effective than vitamin B6 in treating nausea and vomiting in early pregnancy.

RCTRigorous Journal

2014·

14citations

·A. Babaei et al.

Acupressure and vitamin B6 to relieve nausea and vomiting in pregnancy: a randomized study

Acupressure therapy is not more effective than vitamin B6 in reducing nausea and vomiting in early pregnancy.

RCTRigorous Journal

2007·

52citations

·Mattawan Jamigorn et al.

A randomized comparison of ginger and vitamin B6 in the treatment of nausea and vomiting of pregnancy.

Ginger and vitamin B6 both significantly reduce nausea and vomiting during pregnancy, with no significant difference in efficacy between the two treatments.

RCTHighly Cited

2003·

108citations

·M. Sripramote et al.

Studying the antiemetic effect of vitamin B6 for morning sickness: Pyridoxine and pyridoxal are prodrugs

The active antiemetic form of vitamin B6 is pyridoxal 5′ phosphate, which is measurable in pregnancy and correlates with morning sickness symptoms.

RCTRigorous Journal

2014·

11citations

·I. Matok et al.

The effect of Vitamin B6 on chemotherapy induced nausea and vomiting in pediatric cancer

Vitamin B6 significantly reduces chemotherapy-induced nausea and vomiting in children with malignancy, especially in acute lymphocytic leukemia.

RCTVery Rigorous Journal

2020·

1citation

·M. Mousavi et al.

Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial.

Ginger is more effective than vitamin B6 for treating nausea and vomiting in pregnancy, with minor side effects.

RCTHighly Cited

2007·

90citations

·Porndee Chittumma et al.

A comparison between the effects of ginger, pyridoxine (vitamin B6) and placebo for the treatment of the first trimester nausea and vomiting of pregnancy (NVP)

Ginger is more effective than placebo for treating mild to moderate nausea and vomiting in pregnancy, and is comparable with vitamin B6.

RCT

2018·

61citations

·F. Sharifzadeh et al.

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