Vitamin c ferulic acid
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The Synergistic Benefits of Vitamin C and Ferulic Acid in Skincare
Introduction to Vitamin C and Ferulic Acid
Vitamin C (ascorbic acid) and ferulic acid are potent antioxidants widely used in skincare formulations. Vitamin C is known for its ability to neutralize free radicals, boost collagen production, and brighten the skin. Ferulic acid, a plant-based antioxidant, enhances the stability and efficacy of vitamin C, providing additional protection against oxidative stress and photodamage.
Stabilization and Enhanced Efficacy
Stabilization of Vitamin C with Ferulic Acid
One of the primary challenges with vitamin C in skincare is its instability when exposed to air and light. Ferulic acid has been shown to stabilize vitamin C, thereby enhancing its photoprotective properties. A study demonstrated that incorporating ferulic acid into a solution of 15% L-ascorbic acid and 1% alpha-tocopherol (vitamin E) doubled the photoprotection of the skin from solar-simulated irradiation, reducing erythema and sunburn cell formation significantly4.
Enhanced Photoprotection
The combination of vitamins C and E with ferulic acid provides substantial protection against ultraviolet (UV) radiation. Research indicates that this antioxidant complex can significantly reduce the formation of sunburn cells, thymine dimers, and the overexpression of p53 protein, which are markers of UV-induced skin damage2 7. This combination also inhibits apoptosis by reducing the induction of caspase-3 and caspase-7, further protecting the skin from oxidative stress4.
Clinical Applications and Safety
Topical Application and Photodamage Prevention
Topical formulations containing vitamins C and E stabilized by ferulic acid have been shown to protect human skin from UV-induced oxidative stress and photodamage. In a study involving Chinese women, the application of this antioxidant complex significantly protected against solar-simulated UV irradiation-induced acute photodamage, demonstrating its potential as a photoprotective agent2.
Post-Procedure Recovery
The use of a vitamin C, E, and ferulic acid serum following fractional ablative CO2 laser treatment has been reported to shorten post-procedure downtime and improve wound healing. A retrospective chart review found no associated complications with the immediate post-procedure application of this serum, suggesting its safety and efficacy in enhancing recovery3 6.
Conclusion
The combination of vitamin C and ferulic acid in skincare formulations offers enhanced stability and photoprotection, making it a powerful tool against oxidative stress and photodamage. Clinical studies support its efficacy in protecting the skin from UV radiation and improving post-procedure recovery, highlighting its potential benefits in both preventive and therapeutic skincare regimens.
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Most relevant research papers on this topic
Topical application of a commercially available formulation of vitamin C stabilized by vitamin E and ferulic acid reduces tissue viability and protein synthesis in ex vivo human normal skin
Topical application of a commercially available vitamin C formulation stabilized by vitamin E and ferulic acid reduces tissue viability and protein synthesis in ex vivo human normal skin.
Non-RCT
Rigorous JournalProtective effects of a topical antioxidant complex containing vitamins C and E and ferulic acid against ultraviolet irradiation-induced photodamage in Chinese women.
A topical antioxidant complex containing vitamins C, E, and ferulic acid shows potential photoprotective effects against solar-simulated ultraviolet irradiation-induced acute photodamage in human skin.
Safety profile of laser-assisted drug delivery of vitamin C, E, and ferulic acid serum following ablative fractional resurfacing: A retrospective chart review
Topical application of Vitamin C, Vitamin E, and Ferulic acid serum after fractional ablative CO2 laser therapy did not result in associated complications.
Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin.
Ferulic acid improves the stability of vitamins C and E and doubles their photoprotection, providing synergistic protection against oxidative stress in skin, potentially protecting against photoaging and skin cancer.
Highly CitedFerulic acid reverses the cognitive dysfunction caused by amyloid β peptide 1-40 through anti-oxidant activity and cholinergic activation in rats.
Ferulic acid improves cognitive deficits caused by amyloid peptide 1-40 in rats by activating central muscarinic and nicotinic receptors and reducing oxidative stress.
Non-RCT
Animal StudyLaser‐assisted delivery of vitamin C, vitamin E, and ferulic acid formula serum decreases fractional laser postoperative recovery by increased beta fibroblast growth factor expression
Laser-assisted delivery of vitamin C, vitamin E, and ferulic acid serum improves wound healing after fractional laser surgery by increasing beta fibroblast growth factor expression.
Non-RCTRigorous JournalA topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation.
CEFer, a topical antioxidant solution containing vitamins C and E, effectively protects human skin from ultraviolet irradiation, particularly reducing thymine dimer mutations linked to skin cancer.
Non-RCTHighly CitedFerulic Acid Supplementation Improves Lipid Profiles, Oxidative Stress, and Inflammatory Status in Hyperlipidemic Subjects: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Ferulic acid supplementation improves lipid profiles, reduces oxidative stress, and reduces inflammation in hyperlipidemic subjects, potentially reducing cardiovascular disease risk factors.
RCT
Very Rigorous JournalHighly CitedFerulic Acid: A Promising Therapeutic phytochemical and recent patents advances.
Ferulic acid shows promising therapeutic potential against various infections, including malignant growth, diabetes, cardiovascular, and neurodegenerative diseases, with recent patents highlighting its antioxidant properties.
Systematic ReviewHighly CitedDietary Ferulic Acid Supplementation Improves Antioxidant Capacity and Lipid Metabolism in Weaned Piglets
Ferulic acid supplementation improves antioxidant capacity and lipid metabolism in weaned piglets, with increased activity in liver and longissimus dorsi muscle.
RCTAnimal StudyVery Rigorous Journal