Vitamin d fat or water soluble

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Vitamin D: Fat or Water Soluble?

Fat-Soluble Vitamins: Definition and Characteristics

Vitamin D is classified as a fat-soluble vitamin. Fat-soluble vitamins, including vitamins A, D, E, and K, dissolve in fats and oils and are stored in the body's fatty tissues and liver 358. Unlike water-soluble vitamins, which need to dissolve in water before the body can absorb them and cannot be stored, fat-soluble vitamins can be stored in the body for longer periods .

Solubility of Vitamin D

Vitamin D, specifically vitamin D3 (cholecalciferol), is practically insoluble in water but is soluble in fats and organic solvents 146. This characteristic is crucial for its absorption and storage in the body. The solubility of vitamin D3 has been extensively studied in various solvents, confirming its high solubility in fats and poor solubility in water .

Biological Functions and Storage

Vitamin D plays multiple roles in the body, including regulating calcium and phosphate levels, contributing to bone mineralization, and participating in various brain and neurocognitive processes 469. Its fat-soluble nature allows it to be stored in the liver and fatty tissues, ensuring a reserve that the body can draw upon when dietary intake is insufficient 35.

Implications for Health

The ability to store vitamin D means that deficiencies may not become apparent immediately but can develop over time if intake is consistently low. Conversely, because it is stored in the body, excessive intake of vitamin D can lead to toxicity, a condition not typically associated with water-soluble vitamins 36.

Conclusion

Vitamin D is a fat-soluble vitamin, meaning it dissolves in fats and oils and can be stored in the body's fatty tissues and liver. This solubility characteristic is essential for its absorption, storage, and various biological functions. Understanding the solubility and storage mechanisms of vitamin D is crucial for managing its intake and ensuring optimal health.

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Most relevant research papers on this topic

Solubility and thermodynamic function of vitamin D3 in different mono solvents

Vitamin D3 is practically insoluble in water, sparingly soluble in DMSO, PG, and PEG-400, and very soluble in ethanol, IPA, EA, 1-butanol, 2-butanol, and Transcutol®.

2017·

38citations

·Fahad Almarri et al.

Determination of eight water- and fat-soluble vitamins in multi-vitamin pharmaceutical formulations by high-performance liquid chromatography.

The developed reversed-phase HPLC method accurately determines water-soluble vitamins and fat-soluble vitamins in multi-vitamin pharmaceutical formulations, with an average recovery of 78-116%.

Highly Cited

2000·

237citations

·P. Moreno et al.

Vitamins and Minerals

Fat-soluble vitamins can be stored in the body, while water-soluble vitamins need to be taken daily as they are lost in urine.

Highly Cited

2017·

127citations

·R. Perumcheril

Efficacy of vitamin D in the treatment of depression: a systematic review and meta-analysis.

Vitamin D supplementation may be effective in treating depression, as it plays a role in various brain and neurocognitive processes and is linked to various psychiatric disorders.

Meta-Analysis

2021·

13citations

·Ana Lázaro Tomé et al.

Metabolic engineering for the production of fat-soluble vitamins: advances and perspectives

Metabolic engineering strategies show promise in producing fat-soluble vitamins through biotechnological routes, such as transgenic plants, microalgae, and microbial fermentation.

2019·

25citations

·Panhong Yuan et al.

Vitamin D: An Evidence-Based Review

Low vitamin D levels are associated with increased mortality, cancer, and autoimmune diseases, and may increase falls in the elderly.

Literature ReviewHighly Cited

2009·

342citations

·Teresa Kulie et al.

Vitamin D and Infectious Diseases: Simple Bystander or Contributing Factor?

Vitamin D deficiency may contribute to increased incidence and severity of infectious diseases, and monitoring and supplementation may be beneficial in these settings.

Literature ReviewVery Rigorous JournalHighly Cited

2017·

101citations

·P. Gois et al.

Fat-soluble vitamins.

Fat-soluble vitamins, such as vitamin A, vitamin D, vitamin E, and vitamin K, have individual biochemical functions and differ from water-soluble vitamins in their binding to apoenzymes.

1950·

2citations

·T. Moore

Role of vitamin D in female reproduction.

Vitamin D plays a crucial role in female reproduction, influencing ovarian reserve, steroidogenesis, infertility, and the outcomes of IVF, insulin resistance, hyperandrogenism, endometriosis, and polycystic ovary syndrome.

Highly Cited

2016·

95citations

·S. Z. Shahrokhi et al.

Potential Role of Vitamin D for the Management of Depression and Anxiety

Vitamin D supplementation may help reduce symptoms of depression and anxiety, particularly in individuals with major depressive disorder.

Literature ReviewRigorous JournalHighly Cited

2019·

99citations

·G. S. Casseb et al.

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