Is Vitamin B2 (Riboflavin) safe?

Introduction

Vitamin B2, also known as riboflavin, is an essential nutrient that plays a key role in energy production and the metabolism of fats, drugs, and steroids. The safety of riboflavin, particularly when used as a dietary supplement or feed additive, has been evaluated in various studies.

Key Insights from Research Papers

Riboflavin additives derived from genetically modified strains of Bacillus subtilis are considered safe for the target species, consumers, and the environment, with no additional toxicological properties introduced by the phosphate ester monosodium salt form .
There is no evidence that riboflavin is a skin or eye irritant, nor a skin sensitiser, but it may be a respiratory sensitiser in certain forms.
Riboflavin supplementation in adults has been shown to reduce the frequency and duration of migraine attacks without serious side effects, indicating a safe profile for this application.
Normal doses of riboflavin are well tolerated and safe during pregnancy, further supporting its safety profile.
While riboflavin is generally safe, there is a concern regarding the spread of antimicrobial resistance genes due to the presence of genetically modified DNA in some riboflavin (80%) samples.
Supplementation with riboflavin is rarely needed with a normal diet, and there is no known toxicity associated with its intake.

Conclusion

The collective research suggests that riboflavin is safe for use in both humans and animals when sourced and administered appropriately. It is not associated with significant irritant or sensitisation risks, and normal dietary doses are well tolerated across different populations, including pregnant women. However, there are concerns regarding the potential spread of antimicrobial resistance when using certain genetically modified strains in the production of riboflavin. Overall, riboflavin appears to be a safe nutrient with a low risk of toxicity.

Is Vitamin B2 (Riboflavin) safe?

Summary

Consensus Meter

Introduction

Key Insights from Research Papers

Conclusion

Sources and full results

Safety and efficacy of a feed additive consisting of riboflavin‐5′‐phosphate ester monosodium salt (vitamin B2 ) (from riboflavin 98%, produced by Bacillus subtilis KCCM 10445) for all animal species (Hubei Guangji Pharmaceutical Co. Ltd)

The feed additive riboflavin-5′-phosphate ester monosodium salt (vitamin B2) is safe and effective for all animal species, with no toxicological properties added, and does not cause skin/eye irritation or respiratory sensitization.

Safety of the feed additive consisting of vitamin B2/riboflavin (produced by Bacillus subtilis KCCM 10445) for all animal species (Hubei Guangji Pharmaceutical Co. Ltd.)

Vitamin B2/riboflavin produced by Bacillus subtilis KCCM 10445 is safe for all animal species, the consumer, and the environment, with no known skin sensitisation potential.

Riboflavin (vitamin B-2) and health.

Poor riboflavin status contributes to anemia, is associated with cancer risk, and may reduce the metabolism of other B vitamins, affecting overall health.

Safety and efficacy of the feed additive consisting of Vitamin B2/Riboflavin produced by Eremothecium ashbyi CCTCCM 2019833 for all animal species (Hubei Guangji Pharmaceutical Co., Ltd)

The feed additive Vitamin B2/Riboflavin produced by Eremothecium ashbyi CCTCCM 2019833 is safe and effective in meeting animal vitamin B2 requirements, with no environmental concerns.

Supplementation with Riboflavin (Vitamin B2) for Migraine Prophylaxis in Adults and Children: A Review.

Riboflavin supplementation is a safe and well-tolerated option for reducing migraine symptoms in adults, but more evidence is needed to recommend its use as an adjunct therapy for both adults and children with migraine.

Vitamin B2 (Riboflavin)

Riboflavin supplements are used to prevent and treat riboflavin deficiency and prevent migraines, and are generally well-tolerated and safe during pregnancy.

Safety of vitamin B2 (80%) as riboflavin produced by Bacillus subtilis KCCM‐10445 for all animal species

Riboflavin (80%) in animal feed poses a risk for the spread of viable cells and DNA of a genetically modified strain with antimicrobial resistance genes.

Chapter 100 – Vitamin B2 (Riboflavin)

Riboflavin is found in most foods and is essential for maintaining good health, with potential benefits for migraine headaches and cataract prevention.

Vitamin B2: Riboflavin

Riboflavin is a vitamin B2 found in most foods, with the highest content in dairy products, meat, and dark green vegetables.

Safety and efficacy of vitamin B2 (riboflavin 5′‐phosphate ester monosodium salt) for all animal species when used in water for drinking

Riboflavin 5′-phosphate ester monosodium salt is considered safe for all animal species when used in drinking water, but its production strain's safety remains unclear.

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