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These studies suggest circular RNA is more stable, plays significant roles in gene regulation and disease, and can extend protein expression, making it advantageous over linear RNA.
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Circular RNAs (circRNAs) are a novel class of RNA molecules that form covalently closed continuous loops, distinguishing them from the more common linear RNAs. Recent research has highlighted their abundance, stability, and potential functional roles in various biological processes and diseases.
Stability and Resistance to Degradation:
Abundance and Conservation:
Functional Roles:
Potential in Disease Biomarkers and Therapeutics:
Expression Specificity:
Role in Disease Mechanisms:
CircRNAs offer several advantages over linear RNAs, including greater stability, higher abundance, and specific functional roles in gene regulation. Their resistance to degradation and potential as disease biomarkers and therapeutic tools make them a significant focus of current RNA research. These properties underscore the importance of circRNAs in both basic biology and clinical applications.
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