What are tums
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Understanding TUMS: Diverse Contexts and Applications
Twitter-Based User Modeling Service (TUMS)
Twitter-Based User Modeling Service (TUMS) is a sophisticated tool designed to analyze and infer user profiles based on their Twitter activity. This service leverages the vast amount of data generated by users on Twitter to detect topics and extract entities from tweets. By linking tweets to relevant news articles, TUMS enriches the context and provides a structured overview of a user's interests over time. This service is publicly available as a web application and offers user profiles in RDF format, enabling other applications to adapt their functionality based on the user's current interests1.
Tum Variants in Cancer Research
Tum variants refer to immunogenic variants of tumor cells that are produced through mutagen treatment. These variants express new surface antigens that can be recognized by cytolytic T lymphocytes, leading to the rejection of the tumor cells by the immune system. Research has shown that these tum- variants can induce immune protection against the original tumor, providing a potential pathway for cancer immunotherapy. The study of these variants has led to the cloning of specific genes, such as the P91A gene in mouse tumor P815 cells, which has been identified as crucial for the expression of tum- antigens2 4.
Tumefactive Multiple Sclerosis (TuMS)
Tumefactive Multiple Sclerosis (TuMS) is a rare form of multiple sclerosis characterized by large demyelinating lesions that resemble tumors. This condition presents significant diagnostic and therapeutic challenges due to its atypical presentation. A large retrospective multicenter study has been conducted to better understand the clinical characteristics and prognostic factors of TuMS. This research aims to improve the diagnosis and treatment of this complex form of multiple sclerosis3.
Conclusion
The term "TUMS" encompasses a variety of concepts across different fields. In the context of social media, TUMS refers to a Twitter-based user modeling service that provides insights into user interests. In cancer research, tum variants are immunogenic tumor cell variants that offer potential for immunotherapy. Lastly, in neurology, TuMS refers to a challenging form of multiple sclerosis with tumor-like lesions. Each of these applications highlights the diverse and significant implications of TUMS in their respective domains.
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Most relevant research papers on this topic
Tum variants: immunogenic variants obtained by mutagen treatment of tumor cells.
Mutagen treatment of mouse tumor cells produces stable immunogenic variants that induce immune protection against the parental tumor, offering potential for future research.
Defining the course of tumefactive multiple sclerosis: A large retrospective multicentre study
Tumefactive multiple sclerosis (TuMS) presents with tumefactive demyelinating lesions and is associated with a poor prognosis.
Observational StudyImmunogenic (tum-) variants of mouse tumor P815: cloning of the gene of tum- antigen P91A and identification of the tum- mutation.
The tum- variants of mouse tumor P815 express new surface antigens, but induce no detectable antibody response, and the essential role of this mutation in tum- antigen P91A has been identified.
In Vitro Study
Highly CitedTeratocarcinoma cell variants rejected by syngeneic mice: protection of mice immunized with these variants against other variants and against the original malignant cell line.
Each of the "tum-" teratocarcinoma cell variants carries a specific transplantation antigen that is absent from the original tumor cell line and most other tum- variants, potentially offering immune protection against other tum- variants and the original malignant teratocarcino
Non-RCT
Animal StudyHighly CitedBifidobacteria Expressing Tumstatin Protein for Antitumor Therapy in Tumor-Bearing Mice
Bifidobacterium longum with pBBAD-Tum (BL-Tum) effectively inhibits tumor growth and induces apoptosis in tumor-bearing mice, making it a promising gene delivery system for treating tumors.
Non-RCTAnimal Study
Rigorous JournalTumefactive multiple sclerosis (TMS): A case series of this challenging variant of MS.
Tumefactive multiple sclerosis (TMS) is a challenging disease to diagnose, but patients with TMS respond to disease-modifying agents like Glatiramer acetate and Dimethyl fumarate with similar disease progression as relapsing-remitting multiple sclerosis.
Case ReportIdentification of genes encoding T cell defined tum- antigens.
This study successfully cloned tum- gene P91A, a new immunogenic antigen in mouse tumor cells, using a novel method to identify tumor-specific transplantation antigens.
Protection against a nonimmunogenic mouse leukemia by an immunogenic variant obtained by mutagenesis.
Mutagenic leukemia variants can elicit a syngeneic rejection response against nonimmunogenic tumors, potentially providing protection against primary leukemias.
In Vitro StudyHighly CitedTumstatin, a Matrikine Derived from Collagen Type IVα3, is Elevated in Serum from Patients with Non–Small Cell Lung Cancer
Tumstatin levels are significantly higher in patients with non-small cell lung cancer compared to those with idiopathic pulmonary fibrosis, COPD, and healthy controls, providing high diagnostic accuracy.
Observational StudyRigorous Journal