What Are The Benefits And Risks Of Daily Aspirin Use?

Introduction

Daily aspirin use has been widely studied for its potential benefits and risks, particularly in the context of cancer prevention and cardiovascular health. This synthesis aims to provide a cohesive overview of the benefits and risks associated with daily aspirin use based on multiple research studies.

Key Insights

Benefits of Daily Aspirin Use

Cancer Prevention: Daily aspirin use has been shown to reduce the risk of several types of cancer, particularly colorectal cancer, with benefits becoming apparent after 5 years of use .
Reduction in Cancer Mortality: Long-term daily aspirin use is associated with a reduced risk of death due to cancer, especially gastrointestinal cancers .
Cardiovascular Benefits: Daily aspirin use reduces the risk of major vascular events, although this benefit is initially offset by an increased risk of major bleeding .
Ovarian Cancer Risk Reduction: Regular aspirin use, especially low-dose daily aspirin, is associated with a reduced risk of ovarian cancer.
Overall Cancer Incidence: Long-term daily use of adult-strength aspirin may modestly reduce the overall incidence of cancer, particularly colorectal, prostate, and possibly breast cancers.

Risks of Daily Aspirin Use

Gastrointestinal Bleeding: Daily aspirin use increases the risk of gastrointestinal bleeding and peptic ulcers, with higher doses posing a greater risk .
Hemorrhagic Stroke: There is an increased risk of hemorrhagic stroke or hemorrhagic transformation of the original infarct with daily aspirin use .
Bleeding Complications: The risk of bleeding complications varies with the dose of aspirin, with low doses (<100 mg) associated with the lowest risk.

Conclusion

Daily aspirin use offers significant benefits in reducing the risk of several cancers, particularly colorectal cancer, and in preventing major vascular events. However, these benefits must be weighed against the increased risks of gastrointestinal bleeding and hemorrhagic stroke. The decision to use daily aspirin should be personalized, considering individual risk factors for cardiovascular disease and potential adverse effects.

What are the benefits and risks of daily aspirin use?

Summary

Not a yes or no question

Introduction

Key Insights

Benefits of Daily Aspirin Use

Risks of Daily Aspirin Use

Conclusion

Sources and full results

Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials

Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled trials

Alternate-Day, Low-Dose Aspirin and Cancer Risk: Long-Term Observational Follow-up of a Randomized Trial

Aspirin, nonaspirin nonsteroidal anti-inflammatory drug, and acetaminophen use and risk of invasive epithelial ovarian cancer: a pooled analysis in the Ovarian Cancer Association Consortium.

The role of aspirin in cancer prevention

Estimates of benefits and harms of prophylactic use of aspirin in the general population

Indications for early aspirin use in acute ischemic stroke : A combined analysis of 40 000 randomized patients from the chinese acute stroke trial and the international stroke trial. On behalf of the CAST and IST collaborative groups.

Individual and Population Benefits of Daily Aspirin Therapy: A Proposal for Personalizing National Guidelines

Analysis of risk of bleeding complications after different doses of aspirin in 192,036 patients enrolled in 31 randomized controlled trials.

A large cohort study of long-term daily use of adult-strength aspirin and cancer incidence.

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