Vitamin D has significant non-skeletal benefits, including regulation of blood pressure, cardiovascular protection, and reduced incidence and severity of common cancers, autoimmune diseases, and infectious diseases.

Non-musculoskeletal benefits of vitamin D

Optimal vitamin D intake and sensible sunlight exposure can maintain optimal immune system function and reduce the risk of immune-related diseases.

Immunologic Effects of Vitamin D on Human Health and Disease

Vitamin D deficiency is common in athletes, but correcting it through standardized oral supplementation protocols can provide significant musculoskeletal sports health benefits.

Sports Health Benefits of Vitamin D

Increasing vitamin D status globally can improve musculoskeletal health and reduce the risk of chronic illnesses, including cancers, autoimmune diseases, infectious diseases, type 2 diabetes, neurocognitive disorders, and mortality.

Vitamin D for health: a global perspective.

Vitamin D benefits health and diseases at various levels, including cellular, preclinical, and clinical levels, in neonates, children, pregnant women, adults, and elderly individuals.

Benefits of Vitamin D in Health and Diseases

Vitamin D supplementation may enhance athletic performance by regulating immune processes, enhancing skeletal muscle function, and regulating skeletal muscle calcium absorption during cross-bridge cycling.

Vitamin D: Recent Advances and Implications for Athletes

Combined vitamin D and calcium supplementation can reduce fracture risk in older adults, but the effects may be smaller in community-dwelling settings than in institutionalized elderly individuals.

Vitamin D With or Without Calcium Supplementation for Prevention of Cancer and Fractures: An Updated Meta-analysis for the U.S. Preventive Services Task Force

Optimal vitamin D intake and sunlight exposure are crucial for optimal immune system function and preventing immune-related diseases like psoriasis, type 1 diabetes, multiple sclerosis, and autoimmune diseases.

An Update on the Effects of Vitamin D on the Immune System and Autoimmune Diseases

Maintaining vitamin D sufficiency (above 40 ng/mL) through supplements and daily sun exposure is the most cost-effective way to reduce chronic diseases, sepsis, and healthcare costs.

Physiological Basis for Using Vitamin D to Improve Health

Vitamin D deficiency is linked to inflammatory diseases like inflammatory bowel disease, and supplementation may help prevent onset and reduce disease severity.

The Role of Vitamin D in Inflammatory Bowel Disease: Mechanism to Management

Increasing vitamin D levels to 40 ng/mL by daily intake of 2000-3000 IU can reduce the economic burden of diseases like cancer, cardiovascular diseases, and diabetes by euro187,000 million/year in western Europe.

Estimated benefit of increased vitamin D status in reducing the economic burden of disease in western Europe.

Vitamin D supplementation may benefit certain risk groups by improving metabolic variables, reducing oxidative stress, and reducing cardiovascular outcomes.

Effects of Vitamin D on Cardiovascular Risk and Oxidative Stress

Vitamin D deficiency increases the risk of common chronic diseases like cancers, type 1 diabetes, cardiovascular disease, and osteoporosis, and requires adequate intake and annual monitoring.

Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis.

Vitamin D deficiency is linked to increased cardiovascular risk factors, but current evidence suggests vitamin D supplements should not be recommended for CVD prevention.

Vitamin D and cardiovascular health

Vitamin D supplementation reduces the risk of fractures and falls in adults, with potential benefits for other health outcomes, but more controlled clinical trials are needed.

Vitamin D insufficiency.

Vitamin D supplementation has pleiotropic effects on extraskeletal tissues, including the immune, cardiovascular system, pancreatic endocrine cells, muscle, and adipose tissue, potentially benefiting metabolic and autoimmune diseases.

Vitamin D: not just the bone. Evidence for beneficial pleiotropic extraskeletal effects

Vitamin D supplementation reduces fractures in the elderly and may reduce acute respiratory tract infections, but long-term effects on non-skeletal outcomes like type 2 diabetes and cardiovascular disease require further research.

MANAGEMENT OF ENDOCRINE DISEASE: Therapeutics of Vitamin D.

Exposure to sunlight for 15 minutes between 10am-3pm two to three times per week is optimal for synthesis of vitamin D3, which is crucial for maintaining good health.

Why vitamin D is important and how to access the important resources?

Vitamin D supplementation may offer preventive and therapeutic benefits for various chronic nonskeletal disorders, but more large-scale and long-term randomized clinical trials are needed to confirm these findings.

The nonskeletal effects of vitamin D: an Endocrine Society scientific statement.

Maintaining a vitamin D level of >30 ng/mL is crucial for bone health, reducing the risk of chronic diseases, and promoting overall health.

Vitamin D status: measurement, interpretation, and clinical application.

These studies suggest that vitamin D benefits include improved musculoskeletal health, enhanced immune function, reduced risk of chronic diseases, and potential cardiovascular and athletic performance benefits.