This meta-study analyzed genomic, transcriptomic, proteomic, and epigenomic data from 234 studies to gain a comprehensive understanding of neurodegeneration and its various processes.

The Big Picture of Neurodegeneration: A Meta Study to Extract the Essential Evidence on Neurodegenerative Diseases in a Network-Based Approach

Environmental neurotoxicant exposures play a significant role in neurodegeneration in major neurodegenerative diseases like Alzheimer's, Parkinson's, multiple sclerosis, and amyotrophic lateral sclerosis.

The role of environmental exposures in neurodegeneration and neurodegenerative diseases.

Environmental pollutants, such as neurotoxic metals and pesticides, can increase the risk of developing Alzheimer's and Parkinson's diseases, with pre- and post-natal exposure being significant risk factors.

Environmental pollutants as risk factors for neurodegenerative disorders: Alzheimer and Parkinson diseases

Neurodegenerative diseases share common genetic and cellular pathways, offering potential for new treatments and therapeutic approaches.

Converging pathways in neurodegeneration, from genetics to mechanisms

Understanding neuroimmune interactions during development and disease may lead to effective therapies to improve quality of life and reduce the impact of neuroinflammatory and degenerative diseases.

Inflammation in CNS neurodegenerative diseases

Ageing is a primary risk factor for neurodegenerative diseases like Alzheimer's and Parkinson's, and therapies targeting ageing's hallmarks show promise for treating these diseases.

Ageing as a risk factor for neurodegenerative disease

Neuroinflammation plays a common role in the pathogenesis of various neurodegenerative disorders, offering potential therapeutic approaches for these brain disorders.

Neuroinflammation as a Common Feature of Neurodegenerative Disorders

Genetic classification of primary neurodegenerative diseases has improved, revealing common pathological mechanisms and potential treatment strategies for multiple disorders.

Genetic classification of primary neurodegenerative disease.

Common microRNAs dysregulated across neurodegenerative diseases reveal shared molecular mechanisms and could lead to new hypotheses about common molecular mechanisms underlying neurodegeneration.

microRNA dysregulation in neurodegenerative diseases: A systematic review

This review highlights the importance of accurately diagnosing neurodegenerative diseases in older adults, emphasizing their epidemiology, clinical symptoms, and management.

Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases.

A Mediterranean diet, nutritional support, and calorie-controlled diets can protect against cognitive decline and neurodegenerative diseases, while malnutrition and insulin resistance are significant risk factors.

Effect of nutrition on neurodegenerative diseases. A systematic review

Microbial infections may increase susceptibility to neurodegenerative diseases by inducing neuroinflammation and affecting immune responses, which may lead to targeted therapeutic approaches.

Microbial Infections Are a Risk Factor for Neurodegenerative Diseases

Neurodegenerative diseases are characterized by progressive loss of vulnerable neurons, with protein abnormalities in these disorders potentially spreading from cell to cell along anatomically connected pathways.

Pathology of Neurodegenerative Diseases.

Metabolic deficiency in vulnerable neuronal clusters may be the common underlying cause of neurodegenerative diseases, linking various pathologies and offering potential for disease-modifying therapeutic interventions.

Neurodegenerative Diseases – Is Metabolic Deficiency the Root Cause?

Aging contributes to neurodegeneration and neuroinflammation, with the adaptive immune system playing a key role in both degeneration and regeneration of the central nervous system.

Aging and Neurodegenerative Disease: Is the Adaptive Immune System a Friend or Foe?

Uncontrolled inflammation in the central nervous system drives the progression of neurodegenerative diseases, and modulating this inflammatory reaction could be a potential therapeutic strategy.

Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression.

Advances in molecular genetics and technology show promise in understanding and treating neurodegenerative diseases like Alzheimer's, Parkinson's, Huntington's, and ALS, potentially leading to better outcomes and novel therapies.

Unraveling Molecular and Genetic Insights into Neurodegenerative Diseases: Advances in Understanding Alzheimer’s, Parkinson’s, and Huntington’s Diseases and Amyotrophic Lateral Sclerosis

Multiple neurodegenerative pathologies can interact at the molecular level and potentially have additive effects on brain damage, suggesting a cascade of events in the development of neurodegenerative disorders.

Interactions of pathological proteins in neurodegenerative diseases

Cell-to-cell transmission of misfolded proteins, known as 'pathological seeds,' is a common mechanism for the progression of various neurodegenerative diseases, with various factors influencing this process.

Protein transmission in neurodegenerative disease

Impaired mitochondrial function and dynamics are key factors in neurodegenerative diseases like Parkinson's, Huntington's, ALS, and Alzheimer's.

Mitochondrial Dysfunction in Neurodegenerative Diseases

What are the causes and consequences of neurodegenerative diseases?

These studies suggest that neurodegenerative diseases are caused by genetic factors, environmental exposures, and ageing, and result in neuroinflammation, shared molecular mechanisms, and potential for new therapeutic approaches.