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These studies suggest that joint pain is caused by a combination of inflammation, nerve sensitization, mechanical hyperalgesia, structural damage, and psychosocial factors.
19 papers analyzed
Joint pain is a prevalent symptom associated with various conditions, particularly arthritis. Understanding the mechanisms behind joint pain is crucial for developing effective treatments. This synthesis explores the neurophysiological, inflammatory, and structural factors contributing to joint pain, drawing from multiple research studies.
Inflammation and Sensitization:
Neurophysiological Mechanisms:
Structural and Mechanical Factors:
Neuropathic Components:
Psychosocial and Comorbid Factors:
Joint pain arises from a complex interplay of inflammatory, neurophysiological, structural, and psychosocial factors. Inflammation and sensitization of nociceptive pathways are central to the pain experienced in arthritis. Structural damage and mechanical factors further contribute to pain, while neuropathic mechanisms and psychological factors can exacerbate the condition. Understanding these diverse mechanisms is essential for developing comprehensive pain management strategies.
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