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These studies suggest that Parkinson's disease is caused by a combination of genetic mutations, environmental factors, oxidative stress, mitochondrial dysfunction, protein misfolding, and neuroinflammation.
20 papers analyzed
Parkinson's Disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra, leading to motor symptoms such as bradykinesia, resting tremor, and rigidity. The exact causes of PD remain largely unknown, but research has identified both genetic and environmental factors that may contribute to its development.
Genetic Factors:
Environmental Factors:
Oxidative Stress and Mitochondrial Dysfunction:
Protein Aggregation:
Neuroinflammation and Autoimmunity:
Parkinson's Disease is a complex disorder with multiple contributing factors. Genetic mutations, environmental exposures, oxidative stress, mitochondrial dysfunction, protein aggregation, and neuroinflammation all play roles in its pathogenesis. Understanding these diverse mechanisms is crucial for developing effective treatments and potentially finding a cure for this debilitating disease.
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