DNA and RNA share a similar structure and function, but their chemical properties remain largely unresolved.

SOME RELATIONS BETWEEN DNA AND RNA.

A deeper analysis of sequencing data is needed to distinguish true differences between RNA and DNA from potential artifacts.

Comment on “Widespread RNA and DNA Sequence Differences in the Human Transcriptome”

This paper explores potential relationships between DNA and RNA sequences, focusing on their potential roles in cellular development and maintaining characteristics.

AN ANALYSIS OF THE RELATION BETWEEN DNA AND RNA

RNA hairpins show slower conformational dynamics, contributing to their more stable nature and potentially contributing to their different biological roles despite their chemical similarity.

Hairpins under tension: RNA versus DNA

High-throughput sequencing technology errors, not RNA editing mechanisms, explain most of the claimed differences in human cells.

Ribonucleotides in DNA play a crucial role in storing genetic information, influencing the development and function of organisms from bacteria to humans.

Ribonucleotides in DNA: origins, repair and consequences.

Z-DNA and Z-RNA show structural similarities and sequence preferences, but differ in their ability to adopt Z-conformation due to factors like hydration shells, chemical modifications, and junction structures.

Structure and Formation of Z-DNA and Z-RNA

Double-stranded RNA behaves like elastic rods, but shortens when overwound and has a slower transition rate for plectonemic buckling compared to DNA, challenging current nucleic acid mechanics models.

Double-stranded RNA under force and torque: Similarities to and striking differences from double-stranded DNA

Widespread RNA-DNA sequence differences in the human transcriptome reveal an unexplored aspect of genome variation.

Widespread RNA and DNA Sequence Differences in the Human Transcriptome

RNA editing in humans occurs at a much lower frequency than previously proposed, with most RNA-DNA differences observed due to accurate transcription of paralogous sequences.

Very Few RNA and DNA Sequence Differences in the Human Transcriptome

In vitro asymmetric RNA synthesis in bacteria depends on DNA linearity, integrity, and conformation, highlighting the importance of DNA linearity and conformation for asymmetric RNA synthesis.

ASYMMETRIC SYNTHESIS OF RNA IN VITRO: DEPENDENCE OF DNA CONTINUITY AND CONFORMATION.

Nucleotide modifications can enhance the utility of DNA and RNA, potentially leading to semi-synthetic organisms with altered genetic alphabets.

The expanding world of DNA and RNA.

RNA nanotechnology offers diverse applications in medicine due to its flexibility and catalytic functions, with potential applications in diagnostics, therapeutics, and vaccines.

The emerging field of RNA nanotechnology.

RNA and DNA have a diverse range of functions, and new discoveries are revealing new possibilities for chemical biologists to explore and manipulate nucleic acid function in the future.

The expanding view of RNA and DNA function.

Long noncoding RNAs (lncRNAs) play a complex role in transcriptional regulation, epigenetic gene regulation, and disease, despite their relatively low understanding.

Evolution and Functions of Long Noncoding RNAs

Chemical modification of RNA using solid-phase synthesis and enzymatic polymerization can enhance its catalytic or binding properties, aiding in various biological roles and applications.

Chemical methods for the modification of RNA.

RNA interference (RNAi) plays a crucial role in gene silencing and genome regulation, affecting specific genomic regions through epigenetic alterations and meiosis.

RNAi-mediated pathways in the nucleus

RNA-directed DNA methylation (RdDM) plays a crucial role in regulating various plant processes, including transgenerational suppression of transposable element activity, pathogen defense, and developmental transitions.

RNA-directed DNA Methylation

mRNA vaccines show potential immunological utility and toxicity, while plasmid DNA vaccines show greater immunogenicity and clinical trial success.

A Comparison of Plasmid DNA and mRNA as Vaccine Technologies

Plant small RNAs can be categorized into four main groups based on their biogenesis and function, with microRNAs, heterochromatic siRNAs, and natural antisense transcript siRNAs being the most studied subclasses.

Classification and comparison of small RNAs from plants.

What is the difference between DNA and RNA?

Some studies suggest that DNA and RNA have structural and functional similarities, while other studies highlight differences in their conformational dynamics, sequence preferences, and roles in genetic information storage and cellular functions.