What are the effects of cannabidiol on sleep?

Introduction

Cannabidiol (CBD), a non-psychoactive component of Cannabis sativa, has garnered significant attention for its potential therapeutic effects, including its impact on sleep. This synthesis aims to consolidate findings from various studies to understand the effects of CBD on sleep patterns and disorders.

Key Insights

No Significant Effect on Healthy Subjects:
- Acute administration of CBD (300 mg) did not significantly alter the sleep-wake cycle or sleep architecture in healthy volunteers.
Dose-Dependent Effects in Animal Studies:
- In rats, CBD increased total sleep time and slow-wave sleep (SWS) at higher doses (40 mg/kg) but had varying effects on REM sleep latency depending on the dose .
- CBD administered during the light period increased wakefulness and decreased REM sleep, suggesting a potential alerting effect .
Potential Therapeutic Benefits for Sleep Disorders:
- CBD may improve insomnia by increasing REM sleep latency at medium to high doses, although combined use with THC could decrease slow-wave sleep .
- CBD showed promise in reducing nightmares in PTSD patients and improving sleep in chronic pain patients.
Anxiolytic Effects and Sleep:
- CBD's anxiolytic properties may help mitigate anxiety-induced REM sleep disturbances, particularly in PTSD models.
Mixed Results in Human Studies:
- In a study with young adults, CBD combined with THC showed increased wakefulness and reduced stage 3 sleep, indicating alerting properties of CBD.
- Higher doses of CBD (160 mg) were associated with increased sleep duration and reduced dream recall in insomniac volunteers.

Conclusion

The effects of CBD on sleep are complex and appear to be dose-dependent. While CBD does not significantly alter sleep in healthy individuals, it shows potential therapeutic benefits for sleep disorders, particularly through its anxiolytic effects. Animal studies suggest that higher doses of CBD can increase total sleep time and slow-wave sleep, although the impact on REM sleep varies. Further research, especially longitudinal and controlled studies, is needed to fully understand the clinical implications of CBD on sleep.

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What are the effects of cannabidiol on sleep?

Summary

Introduction

Key Insights

Conclusion

Sources and full results

No Acute Effects of Cannabidiol on the Sleep-Wake Cycle of Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study

Acute administration of CBD does not interfere with the sleep cycle of healthy volunteers, supporting the proposal that CBD does not alter normal sleep architecture.

Effects of acute systemic administration of cannabidiol on sleep-wake cycle in rats

Acute systemic administration of CBD increases total sleep time and sleep latency in rats during the light period of the day of administration.

Cannabidiol (CBD) and Insomnia : Literature review

Short-term use of medium to high doses of CBD may improve insomnia, but combined use with THC may decrease slow wave sleep.

Cannabis, Cannabinoids, and Sleep: a Review of the Literature

Cannabidiol (CBD) shows potential for treating insomnia, while THC may improve sleep quality but may impair it long-term.

Hypnoticlike effects of cannabidiol in the rat

Cannabidiol (CBD) increases slow-wave sleep time and decreases wakefulness in rats, with tolerance developing after 15 days of daily injections.

Cannabidiol, a constituent of Cannabis sativa, modulates sleep in rats

CBD increases wakefulness and decreases rapid eye movement sleep in rats, potentially benefiting sleep disorders like excessive somnolence.

Hypnotic and Antiepileptic Effects of Cannabidiol

Cannabidiol (CBD) shows no psychotropic or toxic effects, improves sleep in insomniacs, and shows potential in treating epilepsy refractory to current antiepileptic drugs.

Effect of Δ-9-Tetrahydrocannabinol and Cannabidiol on Nocturnal Sleep and Early-Morning Behavior in Young Adults

Cannabis extracts can disrupt nocturnal sleep and cause memory impairment, sleepiness, and mood changes, while CBD counteracts the sedative effects of THC.

Effect of cannabidiol on sleep disruption induced by the repeated combination tests consisting of open field and elevated plus-maze in rats

CBD effectively blocks anxiety-induced REM sleep suppression in rats, potentially benefiting PTSD patients through its anxiolytic effect.

Effects on sleep and dopamine levels of microdialysis perfusion of cannabidiol into the lateral hypothalamus of rats.

Microdialysis perfusion of CBD into the lateral hypothalamus of rats enhances alertness and suppresses sleep, with increased dopamine levels and prevents sleep rebound after sleep deprivation.

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