What is the evidence of cosmetic oil and skin Absorption?

Introduction

The topic of skin absorption of cosmetic oils and related substances is crucial for understanding potential health impacts and efficacy of topical applications. This synthesis examines the evidence of skin absorption from various cosmetic formulations and oils, focusing on the mechanisms and extent of absorption.

Key Insights

Parabens Absorption:
- Parabens, commonly used as preservatives in cosmetics, show significant skin absorption. The absorption rate depends on the partition coefficient (log P octanol/water), the composition of the cosmetic emulsion, and the time of storage. Higher absorption rates were observed for methyl paraben compared to more lipophilic parabens, with oil/water emulsions facilitating greater absorption than water/oil emulsions.
Oil Absorption in Preterm Babies:
- A study on preterm neonates demonstrated that oils, specifically a mixture of coconut oil and Meadowfoam oil, are absorbed through the skin. Marker fatty acids from Meadowfoam oil were detected in the serum of babies post-application, indicating transcutaneous absorption.
Mineral Oil Contamination:
- Mineral oil hydrocarbons (MOSH) are found to be significant contaminants in the human body, with dermal absorption from cosmetics being a notable source. Factors such as age, body mass index, and the use of specific cosmetic products (sun creams, hand creams, lipsticks) were significant predictors of MOSH levels in fat tissue. This suggests that cosmetics contribute to the accumulation of mineral oils in the body over time.

Conclusion

The evidence indicates that various cosmetic ingredients, including parabens and oils, are absorbed through the skin. The extent of absorption is influenced by the chemical properties of the substances, the formulation of the cosmetic products, and the duration of exposure. Additionally, the use of cosmetics is a significant source of mineral oil contamination in the human body, highlighting the importance of understanding and regulating dermal absorption of cosmetic ingredients.

What is the evidence of cosmetic oil and skin Absorption?

Summary

Introduction

Key Insights

Conclusion

Sources and full results

Percutaneous absorption of parabens from cosmetic formulations

Parabens in cosmetic formulations are absorbed through human skin, with higher fluxes from oil/water emulsions and decreasing lipophilicity as lipophilicity increases, and fluxes becoming constant after about three months of storage.

Transcutaneous absorption of oil in preterm babies--a pilot study.

Preterm babies show transcutaneous absorption of oil, as demonstrated by the presence of marker fatty acids in their serum after oil application.

Evidence for cosmetics as a source of mineral oil contamination in women.

Cosmetics may be a significant source of mineral oil contamination in women, with age, BMI, country of residence, previous childbirths, sun cream use, and daily use of hand creams and lipsticks being significant determinants.

Natural cold pressed oils as cosmetic products

Natural cold pressed oils from seeds and fruit stones can be applied to the skin as cosmetics, with safflower oil showing the best appearance, coconut oil having the best smell, and black currant seed oil showing the best absorbency.

In vivo and in vitro skin absorption of lipophilic compounds, dibutyl phthalate, farnesol and geraniol in the hairless guinea pig.

Lipophilic cosmetic ingredients like dibutyl phthalate, farnesol, and geraniol form reservoirs in skin, and may diffuse out into receptor fluid within 72 hours after application.

In vitro and in vivo percutaneous absorption of retinol from cosmetic formulations: significance of the skin reservoir and prediction of systemic absorption.

The 24-hour receptor fluid value accurately estimates 24-hour in vivo systemic absorption of retinol from cosmetic formulations, with in vitro skin studies useful for determining whether to include absorbable material in in vitro studies.

Review of data on the dermal penetration of mineral oils and waxes used in cosmetic applications.

Mineral oils and waxes used in cosmetic products do not present a risk to consumer health due to their limited dermal penetration and absence of systemic uptake.

In vitro studies on release and human skin permeation of Australian tea tree oil (TTO) from topical formulations.

Australian tea tree oil (TTO) has a reduced permeation capacity in topical formulations, but its effectiveness in cosmetics and pharmaceuticals remains unaffected.

An in silico skin absorption model for fragrance materials.

This study developed and validated a practical skin absorption model for fragrance materials, using 10%, 40%, and 80% default values based on maximum flux, to estimate systemic exposure when experimental data is lacking.

Note on the subcutaneous absorption of oils by rats and mice, with special reference to the assay of œstrin

Subcutaneous absorption of oils in rats and mice is incomplete, with pockets persisting for days or even weeks after injection, highlighting the need for more detailed studies on oil-induced toxicity.

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