What are the health implications of advanced glycation end-products (AGEs)?
Searched over 200M research papers
Summary
10 papers analyzed
These studies suggest that advanced glycation end-products (AGEs) contribute to metabolic dysfunction, cardiovascular diseases, diabetes progression, and various aging-related diseases.
Not a yes or no question
To use the Consensus Meter, try asking a simple yes or no question
Research summarized with Copilot
Beta20 papers analyzed
Introduction
Advanced glycation end-products (AGEs) are a diverse group of compounds formed through the non-enzymatic reaction between reducing sugars and free amino groups in proteins, lipids, and nucleic acids. These compounds accumulate in the body over time and are implicated in various chronic diseases, particularly those associated with aging and metabolic dysfunction.
Key Insights
-
Chronic Diseases and Aging:
- AGEs are linked to the development of chronic degenerative diseases such as cardiovascular disease, Alzheimer's disease, and complications of diabetes mellitus .
- High AGE levels correlate with the progression of diseases like diabetes, cardiovascular disease, and some cancers .
-
Metabolic Dysfunction:
- AGEs contribute to metabolic abnormalities, including insulin resistance and pancreatic β-cell dysfunction, which are central to the development of type 2 diabetes mellitus (T2DM) .
- AGEs promote hypothalamic inflammation, disrupting energy balance and contributing to obesity .
-
Vascular and Cardiovascular Health:
- AGEs contribute to vascular stiffness and atherosclerosis by inducing cross-linking of proteins like collagen and activating the receptor for advanced glycation end products (RAGE) .
- AGEs are associated with the development and progression of heart failure, even in non-diabetic patients.
-
Inflammation and Oxidative Stress:
- AGEs increase inflammation and oxidative stress, which are key mechanisms in the pathogenesis of chronic diseases such as chronic kidney disease and diabetic nephropathy .
- Dietary AGEs can induce systemic inflammation, as evidenced by increased markers like C-reactive protein.
-
Dietary and Exogenous Sources:
- AGEs are formed both endogenously and exogenously, with significant contributions from dietary sources, particularly processed foods common in the Western diet .
- Restricting dietary AGEs has shown positive effects on wound healing, insulin resistance, and cardiovascular health, and may increase lifespan in animal models.
Conclusion
AGEs are implicated in a wide range of health issues, particularly chronic diseases associated with aging and metabolic dysfunction. They contribute to the development of diabetes, cardiovascular diseases, and other chronic conditions through mechanisms involving inflammation, oxidative stress, and disruption of normal cellular functions. Both endogenous formation and dietary intake of AGEs play significant roles in their accumulation and associated health impacts. Reducing AGE intake and targeting AGE-related pathways may offer potential therapeutic benefits.
Sources and full results
Most relevant research papers on this topic
Try another search
descendants of dinosaurs
what animal is most related to dinosaurs
What are the ethical considerations in genetic testing and personalized medicine?
financial literacy
interview guideline about learners' perception towards technology in vocabulary learning
classification of loss of coolant accidents in pressurised water reactor