What is the imapct of the Keto Diet on weight loss?

Introduction

The ketogenic diet (KD) is a high-fat, low-carbohydrate diet that has gained popularity as a weight loss strategy. This diet induces a metabolic state called ketosis, where the body uses fat as its primary energy source instead of carbohydrates. This synthesis aims to present the impact of the ketogenic diet on weight loss based on multiple research studies.

Key Insights

Significant Weight Loss:
- The ketogenic diet leads to substantial weight loss in obese adults, with men losing an average of 18 kg and women 11 kg over 12 weeks.
- Mice on a ketogenic diet showed a significant reduction in body weight, stabilizing at 85% of their initial weight.
- A meta-analysis of randomized controlled trials found that the ketogenic diet significantly reduces body weight in overweight patients with type 2 diabetes mellitus.
Appetite Suppression:
- The ketogenic diet decreases appetite and emotional eating, contributing to weight loss.
- Ketosis suppresses the increase in ghrelin (a hunger hormone) and reduces subjective appetite ratings, which helps in maintaining weight loss.
Metabolic Changes:
- The ketogenic diet induces a unique metabolic state with increased energy expenditure and changes in gene expression related to fatty acid oxidation and lipid synthesis.
- It also leads to significant reductions in insulin and leptin levels, and increases in adiponectin and neuropeptide Y (NPY), which are associated with improved metabolic profiles.
Improved Glycemic Control and Lipid Profiles:
- The ketogenic diet improves glycemic control by lowering glycated hemoglobin and triglycerides, and increasing high-density lipoproteins (HDL) in overweight patients with type 2 diabetes mellitus.
- It also results in a significant drop in glucose levels initially, although these levels return to baseline over time.

Conclusion

The ketogenic diet is effective for significant weight loss, appetite suppression, and metabolic improvements. It induces a unique metabolic state that enhances energy expenditure and alters hormone levels to support weight loss. Additionally, it improves glycemic control and lipid profiles, particularly in overweight patients with type 2 diabetes mellitus. However, the long-term effects of the ketogenic diet require further study to make comprehensive recommendations.

What is the imapct of the Keto Diet on weight loss?

Summary

Introduction

Key Insights

Conclusion

Sources and full results

Weight loss, improved physical performance, cognitive function, eating behavior, and metabolic profile in a 12-week ketogenic diet in obese adults.

A 12-week ketogenic diet effectively reduces weight, improves physical performance, cognitive function, eating behaviors, and metabolic profile in obese adults.

A high-fat, ketogenic diet induces a unique metabolic state in mice.

A very-low-carbohydrate, ketogenic diet induces a unique metabolic state in mice, leading to weight loss and improved glucose tolerance.

Ketogenic Diet Benefits to Weight Loss, Glycemic Control, and Lipid Profiles in Overweight Patients with Type 2 Diabetes Mellitus: A Meta-Analysis of Randomized Controlled Trails

A ketogenic diet effectively promotes weight loss, glycemic control, and improved lipid profiles in overweight patients with type 2 diabetes mellitus.

Mechanism and benefits of ketogenic diet for weight loss and health

The ketogenic diet, a high-fat, low-carbohydrate, and moderate-protein diet, helps in weight loss by shifting energy metabolism from sugar to ketone bodies, providing energy instead of carbohydrates.

Ketosis and appetite-mediating nutrients and hormones after weight loss

Ketogenic diets suppress appetite and alter hormones and nutrients involved in appetite regulation, potentially preventing weight regain.

Metabolic Effects of Ketogenic Diets and Their Utilization in Obesity Management: A Systematic Review

Ketogenic diets can improve health and aid weight loss by mimicking starvation and utilizing fat as a core energy source.

Composition of weight lost during short-term weight reduction. Metabolic responses of obese subjects to starvation and low-calorie ketogenic and nonketogenic diets.

Short-term weight loss in obese subjects is primarily water (61.2%), fat (35.0%), and protein (3.8%), with a mixed diet providing more fat (59.5%) and protein (34.1%).

Ketogenic diets and appetite regulation

Ketogenic diets suppress appetite, potentially improving adherence to energy-restricted diets and weight loss outcomes.

Efficacy of ketogenic diet on body composition during resistance training in trained men: a randomized controlled trial

An 8-week ketogenic diet during resistance training significantly reduced fat mass and visceral adipose tissue in trained men, while non-ketogenic diets showed no significant changes in these parameters.

The ketogenic diet: Pros and cons.

The ketogenic diet can lead to rapid weight loss and favorable biomarker changes, but may increase LDL cholesterol levels and may not be sustainable over time.

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