Health-care systems in low-income and middle-income countries must adapt to the increasing burden of chronic diseases, requiring a shift from acute-centric care to a more comprehensive approach.

Rethinking health-care systems: a focus on chronicity

Non-communicable diseases (NCDs) pose a significant financial burden on healthcare budgets and nations' welfare, with cardiovascular disease being the highest contributor, and costs increasing with severity and years lived with the disease.

The global impact of non-communicable diseases on healthcare spending and national income: a systematic review

A systematic review of grey literature is proposed to capture current thinking on improving healthcare system sustainability in high-income countries.

Towards sustainable healthcare system performance in the 21st century in high-income countries: a protocol for a systematic review of the grey literature

Non-communicable diseases (NCDs) in the European Union account for 25% of health spending and nearly 2% of GDP, posing a significant financial burden on healthcare and economic systems.

The financial burden of non-communicable diseases in the European Union: a systematic review.

Coping strategies for chronic illness costs in low-income and middle-income countries can have detrimental long-term effects on households, requiring qualitative and longitudinal research to understand their impact.

Coping with healthcare costs for chronic illness in low-income and middle-income countries: a systematic literature review

Rare diseases have a significant economic impact on healthcare systems, with drug costs being the main driver, and their impact on patients' quality of life is significant.

The economic and health impact of rare diseases: A meta-analysis

Mixed methods approaches over multiple time points may improve the sustainability measurement of chronic disease health programmes.

How is the sustainability of chronic disease health programmes empirically measured in hospital and related healthcare services?—a scoping review

Effective prevention and management of chronic diseases in older people can significantly reduce disease burden and improve health outcomes.

The burden of disease in older people and implications for health policy and practice

A global goal for chronic disease prevention and control could avert 24 million deaths and save $8 billion in economic output in low-income and middle-income countries over the next 10 years.

The burden and costs of chronic diseases in low-income and middle-income countries

Noncommunicable diseases (NCDs) disproportionately affect poor and vulnerable populations in developing countries, reducing spending on food and education, and impacting national economic growth and poverty-reduction efforts.

The Economic Effect of Noncommunicable Diseases on Households and Nations: A Review of Existing Evidence

Integrated public health and health-care systems can effectively address chronic disease burden by promoting healthy behaviors, early detection, and community collaborations.

Prevention of chronic disease in the 21st century: elimination of the leading preventable causes of premature death and disability in the USA

Preventive policies can lead to greater monetary savings when accounting for comorbidity and super-additivity, resulting in generally underestimated returns from such actions.

The extra cost of comorbidity: multiple illnesses and the economic burden of non-communicable diseases

M-health interventions positively impact chronic disease outcomes in low- and middle-income countries, improving attendance rates, clinical outcomes, and health-related quality of life.

The impact of mobile health interventions on chronic disease outcomes in developing countries: a systematic review.

Chronic diseases are a growing health burden in developing countries, causing 50% of their disease burden in 2005 and costing $84 billion by 2015.

Chronic Diseases in Developing Countries

Chronic diseases in Russia increase household healthcare expenditure, reduce labor supply, and income, but households can insure non-health consumption through transfers, despite high insurance coverage.

The economic impact of chronic diseases: how do households respond to shocks? Evidence from Russia.

A multisectoral approach, focusing on health, education, and innovation, can help reduce the global burden of kidney disease and its complications in all age groups.

The global burden of kidney disease and the sustainable development goals

Chronic kidney disease poses a significant global health challenge, requiring urgent funding for cost-effective interventions and awareness in developing nations.

The Burden of Chronic Kidney Disease on Developing Nations: A 21st Century Challenge in Global Health

Primary health care in low-income and middle-income countries needs a comprehensive approach to prevent and manage chronic diseases, involving pharmacological and psychosocial interventions and long-term follow-up.

Improving the prevention and management of chronic disease in low-income and middle-income countries: a priority for primary health care

Advances in home-based wireless devices, apps, and wearables can improve chronic disease management by monitoring disease metrics in near real time and fostering patient engagement and integrated practice units.

The Role of Technology in Chronic Disease Care.

A One Health approach and public health interventions are needed to combat the intertwined relationship between environmental change and chronic diseases, particularly in small island states.

The interaction of environmental impact and chronic diseases: from theory to practice

What are the implications of high cost chronic diseases on healthcare sustainability?

These studies suggest that high-cost chronic diseases significantly strain healthcare budgets, impact economic systems, and require shifts in care approaches, with effective prevention and management potentially reducing the burden and improving sustainability.