What is coronary heart disease
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Summary
10 papers analyzed
These studies suggest coronary heart disease is caused by the narrowing of coronary arteries due to plaque buildup, leading to reduced oxygen supply to the heart and resulting in chest discomfort, heart attacks, and other complications.
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Understanding Coronary Heart Disease (CHD)
Definition and Pathophysiology of Coronary Heart Disease
Coronary Heart Disease (CHD), also known as Coronary Artery Disease (CAD), is a condition characterized by the narrowing or blockage of the coronary arteries, which supply blood to the heart muscle. This narrowing is primarily due to the buildup of atherosclerotic plaques composed of lipids, calcium, and inflammatory cells on the arterial walls . These plaques can restrict blood flow, leading to chest discomfort (angina) and, if ruptured, can cause a heart attack or myocardial infarction .
Risk Factors for Coronary Heart Disease
Several risk factors contribute to the development of CHD. These include lifestyle factors such as smoking, poor diet, and lack of exercise, as well as medical conditions like diabetes mellitus, hypertension, and hyperlipidemia . Genetic predispositions, such as the association of chromosome 9p21.3, have also been linked to the premature onset of CHD. Additionally, psychosocial stress and obesity are significant contributors to the disease .
Symptoms and Clinical Presentations
The most common symptom of CHD is angina, which manifests as chest pain or discomfort due to reduced blood flow to the heart muscle . Other symptoms may include shortness of breath, fatigue, and in severe cases, heart attack, arrhythmia, or heart failure. The disease can present in various forms, categorized as either acute coronary syndromes (ACS) or chronic coronary syndromes (CCS), depending on the stability and progression of the condition.
Diagnosis and Management
Diagnosis of CHD typically involves assessing blood levels of cholesterol, triglycerides, and lipoproteins, as well as using imaging techniques like angiography . Inflammatory biomarkers such as interleukin-6, C-reactive protein (CRP), and myeloperoxidase (MPO) are also significant in evaluating the severity and prognosis of the disease .
Management of CHD includes lifestyle modifications, pharmacological therapies, and invasive interventions. Medications such as antiplatelet agents, nitrates, beta-blockers, and calcium antagonists are commonly used to relieve symptoms and stabilize the condition . Invasive procedures like percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) are employed in more severe cases to restore adequate blood flow.
Conclusion
Coronary Heart Disease is a serious and prevalent condition that significantly impacts global health. Understanding its pathophysiology, risk factors, and clinical presentations is crucial for effective diagnosis and management. Through a combination of lifestyle changes, medical treatments, and, when necessary, surgical interventions, the progression of CHD can be managed, improving patient outcomes and quality of life.
Sources and full results
Most relevant research papers on this topic
10
Inflammation, atherosclerosis, and coronary artery disease.
10
1,044 Citations
2005