What is in provera
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Understanding Provera: Composition and Uses
Composition of Provera: Medroxyprogesterone Acetate
Provera, also known as medroxyprogesterone acetate, is a synthetic form of the hormone progesterone. It is commonly used in various formulations, including oral tablets and injectable forms. The injectable form, known as Depo-Provera, is particularly notable for its use as a long-acting contraceptive.
Depo-Provera: A Long-Acting Contraceptive
Efficacy and Administration
Depo-Provera is administered as an intramuscular injection of 150 mg/mL once every three months. This method has been in use in the United States for over a decade and worldwide for 40 years, demonstrating its long-term efficacy and safety as a contraceptive option. A newer, lower-dose formulation (104 mg/0.65 mL) allows for subcutaneous injection, which increases convenience and ease of administration while maintaining its effectiveness in suppressing ovulation for more than 13 weeks.
Safety and Side Effects
Long-term clinical experience has established the safety of Depo-Provera, with studies showing no significant increase in the risk of cardiovascular events, breast and gynecologic malignancies, or osteopenia. However, common side effects include changes in the menstrual cycle, body weight, and mood. The return to ovulation after discontinuation of Depo-Provera typically occurs within 30 weeks, with a 97.4% cumulative rate of return to ovulation at 12 months.
Provera in Other Medical Uses
Treatment of Genital Exhibitionism
Provera has also been studied for its effects on male genital exhibitionism. In one study, Provera was shown to significantly reduce serum testosterone levels, although it did not affect penile responsiveness. The study suggested that Provera, combined with assertiveness training, might increase dropout rates in treatment programs for genital exhibitionism, indicating limited effectiveness in this context.
Conclusion
Provera, particularly in its injectable form Depo-Provera, is a highly effective and long-acting contraceptive with a well-established safety profile. It is also used in other medical treatments, such as managing genital exhibitionism, although its effectiveness in such applications may be limited. The development of a lower-dose, subcutaneous formulation of Depo-Provera has further enhanced its convenience and tolerability, making it a versatile option in hormonal therapy.
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