What is lipitor
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Understanding Lipitor (Atorvastatin Calcium)
What is Lipitor?
Lipitor, known generically as atorvastatin calcium, is a medication primarily used to lower cholesterol levels in the blood. It is marketed by pharmaceutical companies Parke-Davis and Pfizer under the trade name Lipitor.
Composition and Formulation
Lipitor tablets are available in various dosages, including 10, 20, 40, and 80 mg of atorvastatin. The tablets also contain several inactive ingredients such as calcium carbonate, candelilla wax, croscarmellose sodium, hydroxypropyl cellulose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, Opadry White YS-1-7040, polysorbate 80, and simethicone emulsion.
Mechanism of Action
Atorvastatin, the active ingredient in Lipitor, functions as a potent hypolipidemic drug by inhibiting HMG-CoA reductase. This enzyme is crucial for the cellular synthesis of cholesterol. By inhibiting this enzyme, atorvastatin increases the expression of LDL receptors, which in turn promotes the hepatic extraction of circulating LDL (low-density lipoprotein).
Clinical Indications
Lipitor is indicated for use in patients who have not achieved desired cholesterol levels through diet alone. It is used to treat primary hypercholesterolemia and combined hyperlipidemia. The medication is particularly effective in lowering LDL cholesterol and triglyceride levels, making it more potent than other available statins.
Dosage and Administration
Lipitor is typically administered in tablet form, with common dosages being 10 mg and 20 mg. The usual starting dose is 10 mg once a day, which can be increased up to 20 mg/day if necessary. In rare and severe cases, the dosage may be increased up to 80 mg/day.
Conclusion
Lipitor (atorvastatin calcium) is a highly effective statin used to manage cholesterol levels in patients with hypercholesterolemia or combined hyperlipidemia. Its mechanism of action involves inhibiting HMG-CoA reductase, thereby reducing cholesterol synthesis and increasing LDL clearance from the bloodstream. Available in various dosages, Lipitor is a versatile option for patients requiring cholesterol management.
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