What is prilosec used for
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Uses of Prilosec (Omeprazole)
Treatment of Reflux Esophagitis
Prilosec for Senile Reflux Esophagitis
Prilosec, also known as omeprazole, is commonly used to treat reflux esophagitis, particularly in elderly patients. A study involving 46 elderly patients with reflux esophagitis demonstrated that Prilosec, when used in combination with Mosapride, significantly improved the condition. The combination therapy was found to adjust stomach secretions and improve gastric motility, leading to a reduction in stomach content reflux. The treatment was effective and safe, with no significant adverse reactions reported1.
Proton Pump Inhibition
Mechanism of Action
Prilosec is a selective and irreversible proton pump inhibitor (PPI). It works by suppressing the secretion of stomach acids, which is beneficial in treating conditions caused by excess stomach acid production. This suppression helps in managing symptoms and promoting healing in acid-related conditions2.
Conclusion
Prilosec (omeprazole) is primarily used to treat conditions related to excess stomach acid production, such as reflux esophagitis. It functions as a proton pump inhibitor, effectively reducing stomach acid secretion. Studies have shown that it is particularly effective in elderly patients when combined with Mosapride, improving both gastric secretions and motility without significant adverse effects.
Sources and full results
Most relevant research papers on this topic
The curative of prilosec joint Mosapride on treating senile reflux esophagitis
Prilosec joint Mosapride effectively reduces stomach content of reflux in elderly patients, with a distinct curative effect and safe drug use.
RCTSite selective syntheses of [(3)H]omeprazole using hydrogen isotope exchange chemistry.
This study demonstrates a controlled and selective labeling of omeprazole with tritium using hydrogen isotope exchange chemistry, potentially benefiting drug discovery and development efforts.
A proton-pump inhibitor expedition: the case histories of omeprazole and esomeprazole
Omeprazole and esomeprazole revolutionized treatment for acid-related disorders by improving antisecretory effects and enhancing clinical effects.
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Highly CitedFDA panel advises against omeprazole as over the counter drug
An FDA panel has advised against allowing omeprazole, the best selling treatment for chronic heartburn, to be sold over the counter due to concerns about patient safety and effectiveness.
Asthma and gastroesophageal reflux: acid suppressive therapy improves asthma outcome.
Acid suppressive therapy with omeprazole improves asthma symptoms and/or peak expiratory flow rates by >20% and pulmonary function in 73% of asthmatics with gastroesophageal reflux after 3 months of therapy.
Non-RCTHighly Cited