What is the difference between metoprolol and metoprolol succinate
Pro Research Analysisby 
Searched over 200M research papers
Differences Between Metoprolol and Metoprolol Succinate
Introduction to Metoprolol and Metoprolol Succinate
Metoprolol is a beta-blocker commonly used to treat cardiovascular conditions such as heart failure (HF) and atrial fibrillation (AF). It works by selectively blocking beta1-adrenergic receptors, which helps to reduce heart rate and blood pressure. Metoprolol is available in two main forms: metoprolol tartrate and metoprolol succinate. While both forms contain the same active ingredient, they have different properties and uses.
Chemical and Physical Differences
Solid-State Structure and Behavior
The solid-state structure and behavior of metoprolol tartrate (MT-o) and metoprolol succinate (MS-m) have been studied extensively. Despite their molecular similarity, they exhibit different behaviors at the macroscopic level. Metoprolol succinate (MS-m) has a slightly greater cohesive energy compared to metoprolol tartrate (MT-o). Additionally, MS-m undergoes a reversible anisotropic lattice expansion and contraction with temperature changes and quickly recrystallizes to its original form after melting. In contrast, MT-o expands and contracts isotropically and forms an amorphous solid upon cooling, which takes several days to revert to its crystalline form.
Clinical Applications and Efficacy
Treatment of Heart Failure and Atrial Fibrillation
Metoprolol succinate is particularly noted for its role in the treatment of heart failure and atrial fibrillation. Clinical studies have shown that metoprolol succinate provides significant benefits in reducing mortality and morbidity in heart failure patients. It is also effective in reducing the incidence of new atrial fibrillation episodes in high-risk patients. These benefits make metoprolol succinate a valuable option in managing these conditions, despite the availability of newer beta-blockers.
Conclusion
In summary, while metoprolol tartrate and metoprolol succinate share the same active ingredient, they differ in their solid-state behaviors and clinical applications. Metoprolol succinate's unique properties make it particularly effective in treating heart failure and atrial fibrillation, offering significant benefits in reducing mortality and morbidity. Understanding these differences is crucial for optimizing treatment strategies in cardiovascular care.
Sources and full results
Most relevant research papers on this topic