What are the latest treatments for eczema and psoriasis?

Introduction

Eczema and psoriasis are chronic inflammatory skin conditions that significantly impact patients' quality of life. Recent advancements in treatment options have provided new avenues for managing these conditions, ranging from traditional therapies to novel biologics and alternative treatments.

Key Insights

Topical Corticosteroids and Calcineurin Inhibitors:
- Topical corticosteroids remain the mainstay treatment for both eczema and psoriasis due to their anti-inflammatory properties .
- Calcineurin inhibitors are frequently prescribed for eczema, especially in cases where corticosteroids are not suitable.
Phototherapy:
- Phototherapy, including broadband UVB, narrowband UVB, and PUVA, is commonly used for more extensive psoriasis and eczema. Despite concerns about carcinogenicity, PUVA remains a popular choice in some regions .
Systemic Therapies:
- Systemic treatments such as methotrexate, retinoids, and ciclosporin are effective for severe cases of psoriasis and eczema but come with significant side effects .
- Newer systemic therapies include immunobiologic agents like monoclonal antibodies, recombinant cytokines, and fusion proteins, which are showing promise in treating psoriasis.
Alternative and Complementary Medicine:
- Patients often turn to complementary and alternative medicine (CAM) therapies, valuing their natural approach and perceived lower risk of side effects. However, the efficacy of CAM varies, and it is less favored for psoriasis and eczema compared to acne.
Novel Topical Treatments:
- Dihydrochalcone derivatives from Populus balsamifera L. buds have shown promising antipsoriatic properties, including anti-inflammatory and antioxidant effects.
- Boswellic acids (Bosexil®) and Vaccinium myrtillus seed oil have demonstrated efficacy in reducing scales, erythema, and itch in both psoriasis and eczema.
- A cream containing dipotassium glycyrrhizinate, Vaccinium myrtillus, epigallocatechin gallatyl glucoside, and Tamarindus indica has shown effectiveness in treating eczema and some improvement in psoriasis, though less effective than traditional corticosteroids.
Hydrocolloid Occlusive Dressings:
- The use of corticosteroids under hydrocolloid occlusive dressings has been effective in treating psoriasis and other dermatoses, providing significant improvement within a week.
Biologic Therapies and IL-17 Inhibitors:
- IL-17 inhibitors are effective in treating psoriasis but may cause paradoxical eczematous eruptions due to shifts in cytokine profiles.

Conclusion

The treatment landscape for eczema and psoriasis includes a variety of options ranging from traditional topical corticosteroids and phototherapy to newer systemic biologics and alternative treatments. While topical corticosteroids and phototherapy remain widely used, novel treatments like dihydrochalcone derivatives, boswellic acids, and CAM therapies are emerging as promising alternatives. Systemic biologics offer new hope for severe cases, though they come with their own set of challenges and potential side effects. The choice of treatment often depends on the severity of the condition, patient preferences, and the risk-benefit profile of the therapies.

What are the latest treatments for eczema and psoriasis?

Summary

Introduction

Key Insights

Conclusion

Sources and full results

Treatment policy for psoriasis and eczema: a survey among dermatologists in the Netherlands and Belgian Flanders.

Topical corticosteroids are the mainstay for treating psoriasis and eczema, with coal tar as a second-choice therapy, and PUVA is frequently prescribed despite its carcinogenicity in Flanders.

Dihydrochalcone Derivatives from Populus balsamifera L. Buds for the Treatment of Psoriasis

Dihydrochalcone derivatives from Populus balsamifera L. buds show promising antipsoriatic properties, potentially contributing to clinical improvement in psoriasis patients.

Therapeutic options in the treatment of psoriasis and atopic dermatitis.

Psoriasis and atopic dermatitis can be effectively treated with various therapeutic options, including local agents, phototherapy, and systemic agents.

Psoriasis treatment: traditional therapy

Traditional treatments for psoriasis include topical therapies, phototherapy, and systemic therapies, with biologic agents being a recent development.

Treatment of psoriasis. Part 1. Topical therapy and phototherapy.

Topical treatments for psoriasis include corticosteroids, noncorticosteroids, and phototherapy, with newer therapies like lasers and light sources being studied.

A Case Series of Patients With Eczematous Eruptions Following IL-17 Inhibitor Treatment for Psoriasis Vulgaris.

IL-17 inhibitor treatment for psoriasis may cause a paradoxical shift favoring an eczematous phenotype, potentially leading to eczematous eruptions in some patients.

Complementary and alternative medicine therapies in acne, psoriasis, and atopic eczema: results of a qualitative study of patients' experiences and perceptions.

Patients with acne, psoriasis, and atopic eczema often use complementary and alternative medicine therapies, which may help reduce psychologic morbidity and improve their sense of control.

A cosmeceutical formulation based on boswellic acids for the treatment of erythematous eczema and psoriasis

A topical formulation of Bosexil® shows promising results for treating psoriasis and erythematous eczema, improving scales and itch without worsening.

Efficacy and Safety of Cream Containing Dipotassium Glycyrrhizinate, Vaccinium myrtillius, Epigallocatechin Gallatyl Glucoside, and Tamarindus indica Compared with Triamcinolone Acetonide Cream in Eczema and Psoriasis

DPG-HERB cream is safe and effective in treating eczema, but less effective in psoriasis compared to triamcinolone acetonide cream.

Treatment of psoriasis and other dermatoses with a single application of a corticosteroid left under a hydrocolloid occlusive dressing for one week.

A single application of corticosteroid under a hydrocolloid dressing can effectively heal psoriasis and other dermatoses within a week, with betamethasone being the most effective treatment.

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