Long-term treatment with antidepressant drugs may worsen depression in susceptible individuals, potentially increasing vulnerability to relapse.

Can long-term treatment with antidepressant drugs worsen the course of depression?

Long-term antidepressant use may worsen depression's long-term outcome and symptomatic expression, potentially increasing vulnerability to relapse.

The mechanisms of tolerance in antidepressant action

Antidepressant usage is linked to long-term cognitive decline and cardiovascular issues, with dementia and hypertension being the most prevalent long-term effects.

Antidepressant’s long-term effect on cognitive performance and cardiovascular system

Long-term antidepressant treatment reduces relapse risk in major affective disorders, but long-term use should be adapted to individual needs and risks, considering potential benefits and risks.

[Long-term clinical effects of antidepressive agents].

Long-term antidepressant treatment can improve depression symptoms, but managing side effects is crucial for patient well-being and treatment adherence.

Tolerability issues during long-term treatment with antidepressants.

Long-term antidepressant treatment improves depression in most patients, but concerns about adverse effects and lack of information on long-term risks persist.

Long-term antidepressant use: patient perspectives of benefits and adverse effects

Stopping antidepressants gradually reduces the risk of relapse and withdrawal symptoms, while abruptly stopping increases the risk of relapse or recurrence.

Discontinuation strategies and long-term outcome of antidepressant medications

Long-term antidepressant treatment for depression is essential, with optimal efficacy and minimizing side effects crucial for patient compliance and sustaining illness remission.

Clinical issues in long-term treatment with antidepressants.

Long-term antidepressant use is associated with common and persistent side effects, with some being more specific to female users.

Side effects of antidepressants during long-term use in a naturalistic setting

Antidepressants interfere with the production and release of catecholamines and indolamines, as well as with the signal transduction of these neurotransmitters, potentially contributing to depression.

Antidepressants and hypothalamic-pituitary-adrenocortical regulation.

Long-term antidepressant treatment for depression is associated with a high prevalence of cognitive and physical side effects, likely due to both drug-related and residual symptoms.

A cross-sectional study of the prevalence of cognitive and physical symptoms during long-term antidepressant treatment.

Prenatal antidepressant exposure is associated with offspring BMI and affective disorders, but not with childhood psychiatric outcomes.

Long-Term Effects of Intrauterine Exposure to Antidepressants on Physical, Neurodevelopmental, and Psychiatric Outcomes: A Systematic Review.

In utero exposure to maternal depression or antidepressants carries risks to the developing fetus, and treatment decisions should be made individually considering both mother and infant's needs.

Acute and long-term behavioral outcome of infants and children exposed in utero to either maternal depression or antidepressants: a review of the literature.

Abrupt discontinuation without psychological support may increase relapse risk and has insufficient evidence on adverse events compared to continuing antidepressants for depressive and anxiety disorders in adults.

Approaches for discontinuation versus continuation of long-term antidepressant use for depressive and anxiety disorders in adults.

Stopping antidepressant therapy in primary care patients is associated with a higher risk of depression relapse by 52 weeks compared to maintaining therapy.

Maintenance or Discontinuation of Antidepressants in Primary Care.

Family intervention is feasible and may carry long-term benefits when there is a loss of clinical effect during long-term antidepressant treatment.

Family intervention approach to loss of clinical effect during long-term antidepressant treatment: a pilot study.

Greater burden of side effects, but not frequency or intensity, is associated with poorer treatment outcome in people with major depressive disorder, even as early as 4 days post-treatment.

Antidepressant side effects and their impact on treatment outcome in people with major depressive disorder: an iSPOT-D report

Antidepressants have selective effects on serotonergic or noradrenergic parameters, which may contribute to their prophylactic effects and contribute to their beneficial effects in depressive episodes.

Delayed pharmacological effects of antidepressants

Antidepressants' effects on sleep depend on the drug, dose, and timing, with some potentially worsening sleep disorders.

Effects of Antidepressants on Sleep

Antidepressants have minimal benefits for major depressive disorder and increase the risk of serious and non-serious adverse events, making their use for adults with depression questionable.

Should antidepressants be used for major depressive disorder?

What are the long term effects of anti-depressants?

Some studies suggest long-term antidepressant use can worsen depression and increase relapse risk, while other studies indicate it can reduce relapse risk and improve symptoms, though concerns about cognitive decline, cardiovascular issues, and side effects remain.