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10 papers analyzed
These studies suggest that aging and longevity are influenced by genetic regulation, metabolic and stress resistance pathways, and mechanisms like autophagy, caloric restriction, and cell-nonautonomous factors.
18 papers analyzed
Aging and longevity are complex biological processes influenced by genetic, environmental, and lifestyle factors. Research has identified several mechanisms that regulate aging and extend lifespan across various species, from yeast to humans. These mechanisms often involve genetic pathways, metabolic regulation, stress resistance, and cellular maintenance processes.
Insulin/IGF-I Signaling Pathway:
Genetic Regulation and Metabolic Pathways:
Cell-Nonautonomous Mechanisms:
Cytoprotective Mechanisms:
Autophagy:
Hormesis and Stress Response:
The mechanisms of aging and longevity are multifaceted and involve a combination of genetic regulation, metabolic control, stress resistance, and cellular maintenance processes. Key pathways such as insulin/IGF-I signaling, cytoprotective mechanisms, autophagy, and hormesis are central to these processes. Understanding these mechanisms can provide insights into promoting healthy aging and extending lifespan across species.
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