Bacteria acquire resistance to antibiotics through various mechanisms, including access to drug targets, changes in antibiotic targets, and direct modification or inactivation of antibiotics.

Molecular mechanisms of antibiotic resistance

Understanding the biochemical and genetic basis of antibiotic resistance is crucial for designing strategies to curtail its emergence and spread, and develop innovative therapeutic approaches against multidrug-resistant organisms.

Mechanisms of Antibiotic Resistance

Antibiotic resistance mechanisms in antibiotic-producing and pathogenic bacteria differ, with new types emerging and antibiotic classes playing a role in resistance development.

Comparison of Antibiotic Resistance Mechanisms in Antibiotic-Producing and Pathogenic Bacteria

Bacteria maintain antibiotic resistance through fitness cost, compensatory evolution, epistasis, and environmental factors, affecting the spread of resistance mutations.

Evolutionary Mechanisms Shaping the Maintenance of Antibiotic Resistance.

Bacteria use natural defense strategies to increase resistance to antibiotics, reducing the ability to combat infections in humans and animals, and the global issue requires research on prevention and alternative antimicrobial methods.

Antibiotic Resistance in Bacteria—A Review

Bacteria develop resistance mechanisms through biochemical and genetic factors, limiting treatment options and compromising effective therapy.

Antibiotic resistance mechanisms in bacteria: biochemical and genetic aspects.

Understanding the mechanisms and epidemiology of antibiotic resistance in gram-negative bacteria is crucial for developing novel antibacterials and guiding individual treatment decisions.

Epidemiology and Mechanisms of Resistance of Extensively Drug Resistant Gram-Negative Bacteria

Understanding molecular mechanisms of antibiotic resistance is crucial for developing new drugs and treating bacterial infections.

Molecular mechanisms of antibiotic resistance.

Understanding the relationships between antibiotic resistance determinants in soil and environmental bacteria can help develop interventions to prevent the recruitment of new or novel genes into pathogens.

Antibiotic Resistance Mechanisms in Bacteria: Relationships Between Resistance Determinants of Antibiotic Producers, Environmental Bacteria, and Clinical Pathogens

Bacteria's adaptability and ability to acquire resistance genes through horizontal gene transfer, mobile genetic elements, and bacterial toxin-antitoxin systems contribute to the rapid spread of antibiotic resistance.

Antibiotics, Resistome and Resistance Mechanisms: A Bacterial Perspective

Staphylococcus aureus drug resistance mechanisms include mec genes, gdpP gene, BORSA and MODSA phenotypes, and various oxazolidinones, glycopeptides, MLS-B, and fluoroquinolones, as well as vir

Molecular Mechanisms of Drug Resistance in Staphylococcus aureus

Epigenetic modifications play a role in antimicrobial resistance, allowing bacteria to rapidly adapt to environmental changes and control gene expressions to resist antibiotic stress, offering new avenues for antibiotic target selection and development.

Antimicrobial resistance and mechanisms of epigenetic regulation

Bacteria can develop resistance to antimicrobial agents through various mechanisms, including intrinsic resistance, acquired resistance, and gene transfer from other organisms.

Mechanisms of antimicrobial resistance in bacteria.

Understanding antibiotic resistance mechanisms in key pathogens can help clinicians select the most appropriate antibiotic for each infection.

Mechanisms of Antibiotic Resistance in Important Gram-Positive and Gram-Negative Pathogens and Novel Antibiotic Solutions

Antimicrobial resistance in bacteria has evolved and continues to emerge, with the widespread use and misuse of antimicrobials contributing to its spread.

Antimicrobial Resistance in Bacteria: Mechanisms, Evolution, and Persistence

Bacteria can develop resistance to antibiotics through limiting uptake, modification of targets, inactivation, and active efflux, leading to limited treatment options and increased morbidity and mortality worldwide.

An overview of the antimicrobial resistance mechanisms of bacteria

Acquired antibiotic resistance genes and mobile genetic elements like plasmids, transposons, and integrons play a crucial role in bacterial resistance to various antibiotics.

Acquired Antibiotic Resistance Genes: An Overview

Target protection, involving various molecular mechanisms, is a key antibiotic resistance mechanism that physically associates with antibiotic targets to rescue them from inhibition.

Target protection as a key antibiotic resistance mechanism

Natural compounds of various origins possess antimicrobial capabilities, including against antibiotic-resistant bacteria, with potential for future therapeutic strategies.

Tackling Antibiotic Resistance with Compounds of Natural Origin: A Comprehensive Review

Phage therapy and CRISPER-Cas precision therapy show potential as effective treatments for multi-drug resistant bacteria, offering more treatment options and alleviating the current drug-resistant crisis.

The Mechanism of Bacterial Resistance and Potential Bacteriostatic Strategies

What is the Mechanisms of antibiotic resistance?

These studies suggest bacteria acquire antibiotic resistance through genetic and biochemical changes, horizontal gene transfer, and environmental factors, necessitating research for new treatments and prevention strategies.