What are the studies on safranal and Alzheimer's disease?

Introduction

Alzheimer's disease (AD) is a prevalent neurodegenerative disorder characterized by progressive cognitive and memory decline. Safranal, a key component of saffron, has been studied for its potential therapeutic effects on AD due to its antioxidant, anti-inflammatory, and neuroprotective properties.

Key Insights

Cognitive Improvement and Neuroprotection:
- Safranal improves cognitive functions and memory in amyloid beta-induced rat models of AD by reducing oxidative stress, inflammation, and apoptosis, and by preserving mitochondrial integrity and neuronal health .
Antioxidant and Anti-inflammatory Effects:
- Safranal exhibits significant antioxidant and anti-inflammatory properties, which help in reducing oxidative damage and inflammation in the brain, contributing to its neuroprotective effects .
Acetylcholinesterase Inhibition:
- Safranal shows moderate inhibitory activity against acetylcholinesterase (AChE), an enzyme involved in the breakdown of acetylcholine, which is crucial for cognitive function. This inhibition may help in managing AD symptoms.
Autophagy Induction:
- Safranal activates the AMPK pathway, leading to autophagy induction, which helps in protecting neurons against amyloid beta toxicity.
Drug-like Properties and Challenges:
- Safranal adheres to several drug-like properties, such as optimal lipophilicity and high plasma protein binding. However, its poor oral absorption due to structural instability poses a challenge for its therapeutic use.

Conclusion

Safranal demonstrates promising potential in the management of Alzheimer's disease through its cognitive enhancement, neuroprotective, antioxidant, anti-inflammatory, and acetylcholinesterase inhibitory effects. However, challenges related to its oral bioavailability need to be addressed to fully harness its therapeutic benefits. Further research is warranted to develop stable, orally absorbable forms of safranal for effective AD treatment.

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What are the studies on safranal and Alzheimer's disease?

Summary

Introduction

Key Insights

Conclusion

Sources and full results

Safranal, an active ingredient of saffron, attenuates cognitive deficits in amyloid β-induced rat model of Alzheimer’s disease: underlying mechanisms

Safranal treatment improves cognitive deficits in Alzheimer's disease-induced rats by preventing neuronal loss and reducing apoptosis, oxidative stress, inflammation, and preserving mitochondrial integrity.

Description of Druglike Properties of Safranal and Its Chemistry behind Low Oral Exposure

Safranal shows promising druglike attributes, but its poor oral absorption is linked to its structural integrity, limiting its potential for Alzheimer's disease treatment.

A Novel Pharmacological Protective Role for Safranal in an Animal Model of Huntington’s Disease

Safranal prevents motor dysfunction in an animal model of Huntington's disease by modulating oxidants-antioxidants balance.

Saffron as a source of novel acetylcholinesterase inhibitors: molecular docking and in vitro enzymatic studies.

Saffron extract shows moderate acetylcholinesterase inhibitory activity, with crocetin and dimethylcrocetin showing potential for developing novel Alzheimer's disease treatments.

Safranal induces autophagy by AMPK activation and protects neurons against amyloid beta in Alzheimer disease

Safranal protects neurons against amyloid beta toxicity by activating the AMPK pathway, potentially offering a potential therapeutic target for Alzheimer's disease.

Protective Effect of Safranal, a Constituent of Crocus sativus, on Quinolinic Acid-induced Oxidative Damage in Rat Hippocampus

Safranal, a constituent of Crocus sativus, effectively protects against oxidative damage in the rat hippocampus, potentially aiding in the prevention and treatment of neurodegenerative disorders like Alzheimer's disease.

Neuroprotective Potency of Safranal Against Neurological Disorders.

Safranal, a component of saffron, shows potential neuroprotective effects against neurological disorders like epilepsy, stroke, multiple sclerosis, Parkinson's, and Alzheimer's disease.

The effects of safranal, a constitute of saffron, and metformin on spatial learning and memory impairments in type-1 diabetic rats: behavioral and hippocampal histopathological and biochemical evaluations.

Safranal and metformin, when combined, improve learning and memory impairments in type-1 diabetic rats, potentially due to their antioxidant, anti-inflammatory, and antiapoptotic properties.

Preventive effect of safranal against oxidative damage in aged male rat brain

Safranal effectively protects aged brains from oxidative damage by increasing antioxidant defenses and restoring lipid peroxidation levels.

Pharmacological effects of Safranal: An updated review

Safranal, the major component of saffron, shows promising pharmacological effects, including antianxiety, anticonvulsant, and neuroprotective effects, as well as antihypertensive, antiaging, and protective effects against metabolic syndrome and diabetic nephropathy.

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