What are the symptoms of mononucleosis (mono)?

Infectious mononucleosis, commonly known as mono, is a clinical syndrome usually caused by the Epstein-Barr virus (EBV). It is characterized by a range of symptoms that can vary in severity and duration.

Key insights from the research papers include:

Patients with infectious mononucleosis often present with sore throat, significant fatigue, palatal petechiae, posterior cervical or auricular adenopathy, and marked or inguinal adenopathy.
During the acute phase of infectious mononucleosis, symptoms such as fatigue, night sweats, and painful neck swelling are significantly more common compared to other upper respiratory tract infections.
Chronic symptoms associated with mononucleosis can include chronic malaise, fatigue, and recurrent upper respiratory tract infections, with some patients experiencing symptoms for more than 2 years.
A subset of patients may develop postinfective fatigue syndrome (PIFS) after infectious mononucleosis, characterized by disabling symptoms and correlated with differential gene expression related to fatigue and musculoskeletal pain.
Some patients report persistent symptoms such as getting tired easily, diurnal somnolence, and depression, which can last several months to over a year after the acute infection.
Athletes who have undergone excessive training may experience symptoms similar to mononucleosis, such as fatigue, rash, swollen glands, joint pains, and sleep disturbances.

In conclusion, infectious mononucleosis can lead to a range of symptoms from acute sore throat and fatigue to chronic malaise and recurrent infections. Some individuals may experience prolonged fatigue and other debilitating symptoms that can persist for months or even years. The severity and duration of these symptoms can significantly impact the quality of life and daily functioning of affected individuals.

What are the symptoms of mononucleosis (mono)?

Summary

Sources and full results

Gene expression correlates of postinfective fatigue syndrome after infectious mononucleosis.

Gene expression correlates of fatigue and musculoskeletal pain symptoms after infectious mononucleosis have been identified, potentially aiding in understanding the pathogenesis of postinfective fatigue syndrome.

Epstein-Barr virus infectious mononucleosis.

Infectious mononucleosis is a viral infection with symptoms ranging from sore throat to fatigue, adenopathy, and atypical lymphocytosis.

Familial chronic mononucleosis.

Chronic mononucleosis in family members may result from altered Epstein-Barr virus-latent states in primary and acquired immunodeficiency states, potentially leading to chronic active infection and a syndrome of chronic mononucleosis.

Acute and chronic symptoms of mononucleosis.

Infectious mononucleosis (IM) causes excessive morbidity in students compared to non-EBV-induced upper respiratory tract infections, with symptoms persisting longer and affecting their quality of life.

Chronic Mononucleosis Syndrome

Chronic mononucleosis syndrome may be a new diagnostic criteria for patients with chronic fatigue and active Epstein-Barr virus infection, with reactivation potentially contributing to symptoms.

The nosology of sub-acute and chronic fatigue syndromes that follow infectious mononucleosis

Two distinct chronic fatigue syndromes exist after infectious mononucleosis, one of which persists even 4 years after onset.

Infectious mononucleosis in athletes.

Infectious mononucleosis may be related to stress and may be an autoimmune disease, with overtraining in athletes often leading to respiratory or mononucleosis-like symptoms.

RETINAL CHANGES WITH ACUTE REDUCTION OF VISION AS INITIAL SYMPTOMS OF INFECTIOUS MONONUCLEOSIS

This case highlights the importance of considering retinal changes as initial symptoms of infectious mononucleosis, as they may lead to a wrong diagnosis due to single symptoms dominating the disease picture.

Epstein Barr virus-specific immune defects in patients with persistent symptoms following infectious mononucleosis.

Persistent symptoms after Epstein-Barr virus mononucleosis may be linked to a defect in EBV-specific immunity, suggesting an immunological basis for the syndrome.

Analysis of immune activation and clinical events in acute infectious mononucleosis.

T cells expressing CD244 and SLAM are responsible for the clinical features of infectious mononucleosis, with increased expression of SAP maintaining control of activation.

Try another search