What are the symptoms of REM sleep behavior disorder?

Introduction

REM sleep behavior disorder (RBD) is a parasomnia characterized by the loss of muscle atonia during REM sleep, leading to the enactment of dreams, which can often be vivid and violent. This disorder is frequently associated with neurodegenerative diseases, particularly synucleinopathies such as Parkinson's disease and dementia with Lewy bodies.

Key Insights

Dream Enactment and Motor Behaviors:
- RBD is marked by vivid, often frightening dreams accompanied by simple or complex motor behaviors during REM sleep, which can be violent and lead to injury .
- Patients exhibit a loss of muscle atonia during REM sleep, allowing them to physically act out their dreams .
Polysomnographic Features:
- Increased electromyographic tone during REM sleep is a key diagnostic feature, often confirmed through polysomnography .
- REM sleep without atonia (RSWA) is a hallmark of RBD, characterized by increased muscle activity during REM sleep .
Association with Neurodegenerative Diseases:
- RBD is strongly associated with neurodegenerative diseases, particularly synucleinopathies such as Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy .
- Idiopathic RBD often precedes the clinical onset of these neurodegenerative diseases by several years .
Non-Motor Symptoms:
- Patients with RBD, especially those with Parkinson's disease, often experience increased non-motor symptoms such as depression, fatigue, sleep disturbances, and orthostatic hypotension .
- There is a notable prevalence of autonomic dysfunction, including orthostatic hypotension, in patients with RBD.
Demographic and Epidemiologic Features:
- RBD predominantly affects older men, with a prevalence of around 0.5% in the general population .
- The disorder can be idiopathic or secondary to other conditions, including the use of antidepressants or neurological diseases .

Conclusion

REM sleep behavior disorder is characterized by the loss of muscle atonia during REM sleep, leading to the enactment of vivid and often violent dreams. This disorder is frequently associated with neurodegenerative diseases, particularly synucleinopathies, and can precede their clinical onset by several years. Key symptoms include complex motor behaviors during sleep, increased muscle activity during REM sleep, and a range of non-motor symptoms such as depression and orthostatic hypotension. RBD predominantly affects older men and can be idiopathic or secondary to other conditions.

What are the symptoms of REM sleep behavior disorder?

Summary

Introduction

Key Insights

Conclusion

Sources and full results

REM sleep behavior disorder

REM sleep behavior disorder (RBD) is a parasomnia characterized by vivid dreams and motor behavior during REM sleep, with potential links to neurodegenerative diseases and synucleinopathies.

REM sleep behaviour disorder

REM sleep behavior disorder (RBD) is characterized by loss of muscle atonia during REM sleep and abnormal behaviors, often causing injury.

Idiopathic REM sleep behavior disorder

Idiopathic REM sleep behavior disorder (RBD) is a parasomnia characterized by lack of motor inhibition during REM sleep, with a strong association to alpha-synucleinopathies and potential neurodegenerative effects.

REM Sleep Behavior Disorder and REM Sleep Without Atonia as an Early Manifestation of Degenerative Neurological Disease

REM sleep behavior disorder and REM sleep without atonia are early manifestations of neurodegenerative diseases, with potential links to Parkinson's disease, Lewy body dementia, and multiple system atrophy.

Parkinson's disease and REM sleep behavior disorder result in increased non-motor symptoms.

REM sleep behavior disorder (RBD) is associated with increased non-motor symptoms in Parkinson's disease patients, particularly depressive symptoms, sleep disturbances, and fatigue.

Manifestations of Parkinson disease differ in association with REM sleep behavior disorder

REM sleep behavior disorder is strongly associated with orthostatic hypotension and autonomic dysfunction in Parkinson's disease patients, but not with other nonmotor manifestations.

REM sleep behavior disorder: Motor manifestations and pathophysiology

REM sleep behavior disorder (RBD) is a common and potentially dangerous disorder in patients with synucleinopathies, predisposing them to Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy within 5 years.

Clinical Overview of REM Sleep Behavior Disorder

REM sleep behavior disorder (RBD) is a parasomnia characterized by unusual motor activities during REM sleep, with high risk for harm to patients or their bedpartners.

Pathophysiologic mechanisms in REM sleep behavior disorder

REM sleep behavior disorder (RBD) is characterized by absence of REM atonia, allowing dream-enacting behaviors, often violent or injurious, and may be induced by medications.

REM sleep behavior disorder

REM sleep behavior disorder (RBD) is a complex sleep disorder associated with periodic limb movements in sleep and can predict other neurologic disorders, such as Parkinson's disease and multisystem atrophy.

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