What are the symptoms of syphilis?

Introduction

Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum, presenting a range of symptoms across its stages.

Key Insights

Secondary syphilis symptoms include pruritus, sore throat, headache, muscle aches, fever, meningismus, hair loss, appetite loss, weight loss, and visual disturbances, with maculopapular lesions being the most common morphologic characteristic.
Ocular symptoms such as visual field loss and photopsia, along with optic disc swelling, can occur during secondary syphilis, potentially leading to significant sequelae if untreated.
Gastric syphilis may present with peptic ulcer-like symptoms, requiring a high index of suspicion for correct diagnosis and appropriate antibiotic therapy.
Oral manifestations of secondary syphilis include malaise, fever, a maculopapular rash on the trunk and extremities, and condyloma lata at the primary infection site.
Syphilitic aortitis is a complication of tertiary syphilis, which can lead to life-threatening symptoms such as aneurysm of the aorta.

Conclusion

Syphilis symptoms are diverse and can affect multiple body systems, including the skin, mucous membranes, eyes, and cardiovascular system. Secondary syphilis is characterized by systemic symptoms and various morphologic lesions, while tertiary syphilis can lead to serious complications such as syphilitic aortitis. Accurate diagnosis and timely treatment are crucial to prevent severe consequences.

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What are the symptoms of syphilis?

Summary

Introduction

Key Insights

Conclusion

Sources and full results

The Signs and Symptoms of Secondary Syphilis

Secondary syphilis symptoms include pruritus, sore throat, headache, muscle aches, fever, meningismus, loss of appetite, weight loss, and visual disturbances.

Do not lose sight of syphilis

Syphilis can cause ocular manifestations, such as bilateral treponemal optic neuritis, which can be treated with oral prednisone and intravenous penicillin G, improving visual acuity.

Gastric syphilis: a disease with multiple manifestations.

Gastric syphilis can be mistaken for peptic ulcer disease and treated effectively with penicillin, highlighting the need for clinicians to recognize this disease and implement appropriate antibiotic therapy.

Oral Secondary Syphilis

Secondary syphilis develops in 25% of patients infected with Treponema pallidum, causing systemic symptoms, fever, and maculopapular rash.

Syphilitic aortitis in secondary syphilis.

Syphilitic aortitis is a rare complication of tertiary syphilis, but early diagnosis is crucial for preventing life-threatening symptoms and preventing aneurysms.

Syphilis: Review with Emphasis on Clinical, Epidemiologic, and Some Biologic Features

Syphilis is a chronic disease caused by Treponema pallidum, with various stages and varying incidence worldwide, and penicillin remains the mainstay of therapy.

The diagnosis of cardiovascular syphilis; analysis of clinical and post-mortem findings☆

Cardiovascular syphilis is a rare and often fatal condition, with symptoms often present but not related to heart disease, and adequate therapy may relieve symptoms and prolong life.

Syphilis, the Great Imitator—Clinical and Dermoscopic Features of a Rare Presentation of Secondary Syphilis

Secondary syphilis can present as a rare presentation with atypical clinical symptoms, and dermoscopy may aid in its recognition.

Reexamining Syphilis: An Update on Epidemiology, Clinical Manifestations, and Management

Syphilis rates are increasing globally, with penicillin being the preferred treatment for various stages, and clinicians should be aware of its signs and symptoms to effectively manage and treat the disease.

Cutaneous Manifestations of Syphilis

Syphilis has diverse cutaneous manifestations, and clinicians should be aware of its diverse clinical symptoms and complex diagnostics to effectively diagnose and manage the disease.

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