Secondary syphilis symptoms include pruritus, sore throat, headache, muscle aches, fever, meningismus, loss of appetite, weight loss, and visual disturbances.

The Signs and Symptoms of Secondary Syphilis

Syphilis diagnosis and treatment involve a nontreponemal test and a treponemal-specific test, with penicillin G being the first-line therapy for all stages.

Diagnosis and management of syphilis.

Syphilis is a chronic disease caused by Treponema pallidum, with various stages and varying incidence worldwide, and penicillin remains the mainstay of therapy.

Syphilis: Review with Emphasis on Clinical, Epidemiologic, and Some Biologic Features

Syphilis should be considered a diagnosis in sexually active HIV-infected individuals, as neurosyphilis and syphilitic hepatitis can cause neurological symptoms and require different treatments.

Syphilitic hepatitis and neurosyphilis: an observational study of Danish HIV-infected individuals during a 13-year period

Syphilis begins with superficial lesions and progresses to deeper and more serious manifestations, often without causing symptoms for some time.

Syphilis—Signs, Symptoms, and Treatment

Oral presentations of secondary syphilis are common and challenging for diagnosis, even in patients with epidemiological risk factors.

Oral forms of secondary syphilis, an illustration of the pitfalls set by the great imitator.

Intravenous penicillin G effectively resolved painful anogenital lesions and improved dermatological, oropharyngeal, laryngeal, and neurological symptoms in a 53-year-old woman with atypical syphilis presentation.

Painful rash with hoarseness: an atypical presentation of syphilis

Syphilis can be cured completely, except for tissue destruction prior to therapy, in all stages except for metasyphilis.

[Syphilis. Clinical aspects of Treponema pallidum infection].

Secondary syphilis develops in 25% of patients infected with Treponema pallidum, causing systemic symptoms, fever, and maculopapular rash.

Oral Secondary Syphilis

HIV infection increases the frequency of early neurosyphilis and reduces the response to penicillin, requiring intensive therapy and follow-up observation.

Effect of human immunodeficiency virus (HIV) infection on the course of syphilis and on the response to treatment.

Ocular syphilis presents with various clinical findings and no significant ocular manifestations without acute syphilitic posterior placoid chorioretinitis.

Clinical Features of Syphilis Patients with Ocular Symptoms as the Initial Manifestation

Syphilitic bilateral papillitis mimicking papilloedema is a nonspecific sign in syphilis patients, and differential diagnosis is crucial for accurate treatment.

Diagnosis of Syphilitic Bilateral Papillitis Mimicking Papilloedema

Syphilis rates are increasing globally, with penicillin being the preferred treatment for various stages, and clinicians should be aware of its signs and symptoms to effectively manage and treat the disease.

Reexamining Syphilis: An Update on Epidemiology, Clinical Manifestations, and Management

Syphilis is a complex infectious disease with multiple stages and risk factors, and its diagnosis and treatment during pregnancy require careful monitoring and monitoring of response to treatment.

Update on syphilis and pregnancy

Self-reported neurologic and ocular symptoms are low in early syphilis cases, and only one-third of those who self-reported symptoms underwent further recommended diagnostic evaluation.

Prevalence of Self-Reported Neurologic and Ocular Symptoms in Early Syphilis Cases.

Syphilitic aortitis is a rare complication of tertiary syphilis, but early diagnosis is crucial for preventing life-threatening symptoms and preventing aneurysms.

Syphilitic aortitis in secondary syphilis.

Secondary syphilis can present as a rare presentation with atypical clinical symptoms, and dermoscopy may aid in its recognition.

Syphilis, the Great Imitator—Clinical and Dermoscopic Features of a Rare Presentation of Secondary Syphilis

Syphilis, a sexually transmitted disease caused by Treponema pallidum, has rebounded in the 21st century, especially among men who have sexual contact with other men, with symptoms and treatment methods varying according to European guidelines.

Syphilis - a disease that still occurs

Secondary syphilis with extragenital chancre on the nipple can be identified by pathology and serological examination, emphasizing the importance of identifying special site's pruritus erythema.

A Case of Secondary Syphilis with the Extragenital Chancre on the Nipple

Syphilis is a persistent infection caused by Treponema pallidum, with a global public health problem emerging due to its prevalence in low-income countries and the difficulty of diagnosing and treating it.

A Review on Syphilis: Clinical Manifestation and Epidemiology

These studies suggest that the symptoms of syphilis include pruritus, sore throat, headache, muscle aches, fever, meningismus, loss of appetite, weight loss, visual disturbances, systemic symptoms, and a maculopapular rash.