What are the symptoms of uterine cancer?
Searched over 200M research papers
Research Analysis by Consensus
Consensus Meter
Symptoms of Uterine Cancer
Uterine cancer, a significant gynecological malignancy, presents with various symptoms that can aid in early diagnosis and treatment. Understanding these symptoms is crucial for timely medical intervention.
Abnormal Uterine Bleeding
Postmenopausal Bleeding
Postmenopausal bleeding is one of the most significant and common symptoms associated with uterine cancer. Studies have shown that this symptom has a high odds ratio (OR = 160) for predicting uterine cancer, making it a critical indicator for further investigation. The sensitivity of postmenopausal bleeding as a symptom varies widely, but it remains a primary focus in diagnosing uterine malignancies.
Excessive and Irregular Vaginal Bleeding
Excessive vaginal bleeding and irregular menstruation are also strongly associated with uterine cancer. These symptoms have been quantified with significant odds ratios (OR = 22 and OR = 42, respectively). Abnormal uterine bleeding is often the first symptom that prompts women to seek medical advice, especially in pre- and perimenopausal women.
Vaginal Discharge
Unusual vaginal discharge is another symptom linked to uterine cancer. This symptom has an odds ratio of 14, indicating a notable association with the disease. The presence of abnormal discharge should prompt further diagnostic evaluations to rule out malignancy.
Pelvic Pain and Pressure
Pelvic pain and a sensation of pressure in the pelvic area are reported symptoms in women with uterine cancer. These symptoms can be due to the tumor's growth and its impact on surrounding tissues and organs. Abdominal pain, specifically, has an odds ratio of 2.0, highlighting its relevance as a symptom.
Systemic Symptoms
Fatigue and Psychological Distress
Fatigue is a common symptom experienced by patients with uterine cancer, often exacerbated by treatments such as radiotherapy . Psychological distress, including anxiety and depression, is also prevalent and significantly correlates with general fatigue.
Hematuria and Low Hemoglobin
Hematuria (blood in urine) and low hemoglobin levels are additional symptoms that have been associated with uterine cancer. Hematuria has an odds ratio of 8.7, while low hemoglobin has an odds ratio of 2.1, indicating their importance in the diagnostic process.
Gastrointestinal and Other Symptoms
Loss of Appetite and Weight Loss
Patients with uterine cancer may experience a loss of appetite and subsequent weight loss. These symptoms, along with general weakness and anemia, are indicative of the systemic impact of the disease.
Nausea, Vomiting, and Diarrhea
During treatments like radiotherapy, patients often report increased nausea, vomiting, and diarrhea, which are significantly correlated with general fatigue and a decrease in quality of life.
Conclusion
Recognizing the symptoms of uterine cancer, such as abnormal uterine bleeding, unusual vaginal discharge, pelvic pain, systemic fatigue, and gastrointestinal issues, is essential for early diagnosis and effective treatment. These symptoms, supported by various studies, highlight the need for prompt medical evaluation to improve patient outcomes.
Sources and full results
Most relevant research papers on this topic