Will metformin cause hair loss
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Summary
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These studies suggest metformin may promote hair regrowth in certain conditions.
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Metformin and Hair Loss: Analyzing the Evidence
Introduction to Metformin and Hair Health
Metformin is a widely used medication primarily prescribed for managing type 2 diabetes. It is known for its glycemic control properties and has been studied for various other potential health benefits. A common concern among patients is whether metformin can cause hair loss. This article synthesizes the findings from recent research to address this concern.
Metformin and Hair Regrowth in Alopecia
Central Centrifugal Cicatricial Alopecia (CCCA)
One study explored the effects of topical metformin on patients with Central Centrifugal Cicatricial Alopecia (CCCA), a type of scarring alopecia predominantly affecting women of African descent. The study reported hair regrowth in two patients after the application of topical metformin. This suggests that metformin may have a positive effect on hair health, particularly in conditions involving fibrosis, by mediating adenosine monophosphate-activated protein kinase (AMPK).
Metformin and Hair Cell Protection
Gentamicin-Induced Hair Cell Death
Another study investigated metformin's protective effects against gentamicin-induced hair cell death. In vitro experiments showed that metformin could block the translocation of endonuclease G into the nucleus of outer hair cells, thereby attenuating hair cell loss. However, in vivo studies did not support these findings, as metformin did not prevent gentamicin-induced ototoxicity and, in some cases, exacerbated the condition when combined with gentamicin at higher dosages.
Conclusion
Current research does not support the notion that metformin causes hair loss. On the contrary, there is evidence suggesting that metformin may promote hair regrowth in specific types of alopecia and protect hair cells under certain conditions. However, more extensive in vivo studies are needed to fully understand the implications of metformin on hair health. Patients concerned about hair loss should consult their healthcare provider for personalized advice.
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