Women cancer most common
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Summary
10 papers analyzed
These studies suggest that breast cancer is the most common cancer among women, with incidence and mortality influenced by genetic, biological, and sociodemographic factors.
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Most Common Cancer Among Women: Breast Cancer
Breast Cancer Incidence and Mortality
Breast cancer is the most common cancer among women globally, both in developed and developing regions. It accounts for one in ten of all new cancer diagnoses worldwide each year and is the leading cause of cancer-related deaths among women . The incidence and mortality rates of breast cancer have been increasing over the past few decades, with significant geographical variations. In China, for instance, breast cancer remains the most prevalent cancer among women, highlighting the need for effective prevention and control measures.
Genetic Factors and Breast Cancer Risk
Genetic predisposition plays a crucial role in breast cancer risk. Large-scale genotyping studies have identified numerous loci associated with breast cancer susceptibility. For example, a meta-analysis of genome-wide association studies (GWAS) identified 41 new breast cancer susceptibility loci, suggesting that over 1,000 additional loci may be involved in breast cancer risk. Additionally, up to 30% of breast cancer cases in the United States have a familial link, with specific single nucleotide polymorphisms (SNPs) explaining a significant portion of this risk.
Breast Cancer in Elderly Women
The risk of breast cancer increases with age, making it the most common malignancy among elderly women. Studies have shown that women aged 80 and over tend to have larger tumors, more frequent lymph node involvement, and higher rates of distant metastases compared to younger patients. These older patients also exhibit different tumor characteristics, such as lower grades and higher hormone sensitivity, which can influence treatment outcomes and mortality rates.
Disparities in Breast Cancer Survival
Survival rates for breast cancer vary significantly across different regions and demographic groups. Globally, the 1-, 3-, 5-, and 10-year survival rates for breast cancer are 92%, 75%, 73%, and 61%, respectively. However, these rates are generally lower in developing regions compared to developed ones, reflecting disparities in healthcare access and treatment quality. In the United States, black women have a lower 5-year survival rate compared to white women, a disparity that has persisted despite advances in detection and treatment.
Conclusion
Breast cancer remains the most common and deadly cancer among women worldwide. Genetic factors, age, and regional disparities significantly influence the incidence, characteristics, and survival rates of breast cancer. Addressing these disparities through improved screening, treatment, and access to healthcare is crucial for reducing the global burden of this disease.
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