Zestril medication
Pro Research Analysisby 
Searched over 200M research papers for "zestril medication"
Zestril Medication: Efficacy, Bioequivalence, and Safety
Efficacy of Zestril in Hypertension Treatment
Zestril (Lisinopril), an angiotensin-converting enzyme (ACE) inhibitor, has been extensively studied for its effectiveness in treating hypertension. In a study conducted in Nigeria, 51 patients with mild to moderate essential hypertension were treated with Zestril in doses ranging from 10 mg to 40 mg daily. The results showed a significant reduction in mean diastolic blood pressure after 16 weeks, with 70% of patients achieving controlled blood pressure levels (diastolic BP ≤ 90 mm Hg). Another multicenter study involving 100 patients with slight to moderate hypertension found that Zestril was effective in 88.4% of cases, with most patients achieving normal pressure values with a 20 mg daily dose.
Bioequivalence of Zestril and Other Brands
The bioequivalence of Zestril compared to other lisinopril brands has also been evaluated. A study involving 28 healthy volunteers compared Zestril (AstraZeneca, UK) with Lisotec (Julphar, UAE). The pharmacokinetic parameters, including AUC and CMAX, showed no significant differences between the two formulations, indicating that Lisotec is bioequivalent to Zestril. Another study compared the in vitro release of Zestril with Lizinocor, a lisinopril product from Georgia, and found that both had comparable release profiles, with Zestril showing a slightly lower release percentage.
Renal Protection and Microprotein Effects
Zestril has been shown to offer additional benefits beyond blood pressure control. In a study comparing Zestril with amlodipine, Zestril was more effective in reducing urine microalbumin levels, indicating better renal protection in patients with essential hypertension. This suggests that Zestril not only helps in managing blood pressure but also in protecting kidney function.
Safety and Adverse Effects
While Zestril is generally well-tolerated, some patients may experience adverse effects. In the Nigerian study, 27% of patients reported side effects, with cough being the most common. Additionally, a case report highlighted a rare instance of isolated uvular angioedema associated with Zestril use, emphasizing the need for awareness of potential severe reactions.
Quality Concerns in Different Markets
The quality of Zestril and other lisinopril brands in different markets has been a concern. A study in Sudan assessed the pharmaceutical equivalence of five brands of lisinopril, including Zestril. While all brands passed most official tests, Zestril failed the hardness test, indicating potential quality issues related to excipient variations. This underscores the importance of stringent quality control measures to ensure the safety and efficacy of medications.
Conclusion
Zestril (Lisinopril) is a highly effective and well-tolerated medication for treating hypertension, with additional benefits for renal protection. It has been shown to be bioequivalent to other lisinopril brands, ensuring its reliability across different formulations. However, attention to potential adverse effects and quality control in various markets is crucial to safeguard patient health.
Sources and full results
Most relevant research papers on this topic