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These studies suggest zinc supplementation may reduce depressive symptoms and enhance the efficacy of antidepressant treatments, but more research is needed to confirm its effectiveness as a stand-alone therapy.
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Depression is a significant public health issue, and there is growing interest in the potential role of zinc supplementation in its treatment. Zinc is an essential trace mineral involved in various brain functions, and its deficiency has been linked to depressive symptoms. This synthesis aims to evaluate the evidence from multiple studies on whether zinc can help treat depression.
Zinc Supplementation as an Adjunct to Antidepressants:
Zinc Monotherapy:
Zinc and Depression Risk:
Mechanisms of Action:
The collective evidence suggests that zinc supplementation can be beneficial in treating depression, particularly when used alongside conventional antidepressant medications. Zinc monotherapy also shows promise, especially in specific populations like overweight or obese individuals. Additionally, higher dietary zinc intake is associated with a reduced risk of developing depression. Further research is needed to confirm these findings and to better understand the mechanisms through which zinc exerts its antidepressant effects.
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