Paper

αβ T Cell Receptor Mechanosensing Forces out Serial Engagement

Published Jul 4, 2018 · Yinnian Feng, E. Reinherz, M. Lang

Trends in immunology

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Abstract

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Study Snapshot

The T cell receptor (TCR) is a mechanosensor whose force-dependent structural transition and allostery regulate peptide discrimination and pMHC bond lifetime, suggesting a digital mechanosensing mechanism for T cell activation and potential new approaches for cytotoxic T lymphocyte

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

αβ T Cell Receptor Mechanosensing Forces out Serial Engagement

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