β-Amino acid derivatives as mitochondrial complex III inhibitors of L. donovani: A promising chemotype targeting visceral leishmaniasis.

doi:10.1016/J.EJMECH.2019.111632

Paper

β-Amino acid derivatives as mitochondrial complex III inhibitors of L. donovani: A promising chemotype targeting visceral leishmaniasis.

Published Nov 15, 2019 · Pragya Chandrakar, Naresh Gunaganti, Naveen Parmar

European journal of medicinal chemistry

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3

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Abstract

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In Vitro Study

Study Snapshot

-amino acid derivatives show promising antileishmanial efficacy against L. donovani, with 10c effectively reducing spleen and liver parasite burden without hepatotoxicity.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

β-Amino acid derivatives as mitochondrial complex III inhibitors of L. donovani: A promising chemotype targeting visceral leishmaniasis.

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