Synthesis and antioxidant properties of new (2,4- and 3,4-dimethoxyphenyl)-1,2,4-triazoles

Paper

Synthesis and antioxidant properties of new (2,4- and 3,4-dimethoxyphenyl)-1,2,4-triazoles

Published 2022 · Dmitro V. Dovbnya, A. Kaplaushenko, Yu. S. Frolova

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Abstract

The purpose of the work is to develop preparative methods for the synthesis of ((5-(2,4and 3,4-dimethoxyphenyl)-3H-1,2,4-triazole-3-yl)thio)aceto(propano-, butano-, benzo)nitriles, to investigate the reaction of acid hydrolysis, to receive the physical-chemical properties of the synthesized compounds, and to study antioxidant activity of new compounds. Preparative methods for the synthesis of (5-(2,4and 3,4-dimethoxyphenyl)-3H-1,2,4-triazole-3-yl)thio)aceto(propano-, butano-, benzo)nitriles have been developed for which studied the reaction of acid hydrolysis, resulting in the production of carboxylic acids. The structure of the obtained substances was confirmed by modern physical-chemical methods. The antioxidant activity of the synthesized compounds was evaluated in vitro by the method of the non-enzymatic initiation of BOD with salts of iron (II).

Study Snapshot

New (2,4- and 3,4-dimethoxyphenyl)-1,2,4-triazoles have been synthesized and shown to have antioxidant properties in vitro.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Synthesis and antioxidant properties of new (2,4- and 3,4-dimethoxyphenyl)-1,2,4-triazoles

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